供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-0039 |
CAS号: | 详见产品说明书 |
DNA修复酶相互作用蛋白抗体
〖别名〗2010301N04Rik; AI452191; Aplf; APLF_HUMAN; Aprataxin and pnk-like factor; Apurinic-apyrimidinic endonuclease APLF; C2orf13; PNK and APTX like FHA protein; PNK and APTX-like FHA domain-containing protein; RGD1565557; XIP1; XRCC1 interacting protein 1; XRCC1-interacting protein 1.
〖浓度〗1mg/1ml
〖规格〗DNA修复酶相互作用蛋白抗体0.2ml/200μg
〖抗体来源〗Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗Human, Mouse, Rat
〖产品类型〗一抗
〖研究领域〗细胞生物 细胞周期蛋白 表观遗传学
〖蛋白分子量〗predicted molecular weight: 57kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated synthetic peptide derived from human APLF
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
〖产品应用〗WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗APLF is a 511 amino acid protein that contains one FHA doman and two C2H2type zinc fingers. Localized to both the nucleus and the cytoplasm, APLF interacts with XRCC1, XRCC4 and Ku-86 and, via these interactions, is involved in single-strand and double-strand DNA break repair. APLF is subject to post-translational phosphorylation in response to DNA breaks. The gene encoding APLF maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.
Function : Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.
Subunit : Interacts with LIG4, PARP1, XRCC1, XRCC4 and XRCC5.
Subcellular Location : Nucleus. Cytoplasm; cytosol. Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers.
Post-translational modifications : Poly-ADP-ribosylated. In addition to binding non covalently poly(ADP-ribose) via its PBZ-type zinc fingers, the protein is also covalently poly-ADP-ribosylated by PARP1.
Phosphorylated in an ATM-dependent manner upon double-strand DNA break.
Similarity : Belongs to the APLF family.
Contains 1 FHA-like domain.
Contains 2 PBZ-type zinc fingers.
Database links : UniProtKB/Swiss-Prot: Q8IW19.1
本公司产品现货供应,货期短,质量可靠。仅用于科研实验不应用于临床。我们用专业的态度,一流的服务,全程实验指导,让你的数据不在成为实验奇谈。选择优质的DNA修复酶相互作用蛋白抗体,你的小伙伴都会惊呆的。本公司专业供应各种进口、国产一抗及二抗。代理品牌有R&D、Santa Cruz、Bipec、Millipore等国际知名品牌,品种多达7000多种。让你的科研之路不再布满荆棘。
我们还可以为客户提供产品说明书。DNA修复酶相互作用蛋白抗体拥有高纯度、高效价、高特异性的特点,可以应用于多种实验。免费送货上门,为您大大节省了时间和金钱。
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Ab-(001)-02016 Anti-phospho-CYLD(Ser418) 磷酸化微管结合蛋白CYLD抗体 ,英文名: Anti-phospho-CYLD ,规格: 0.1ml
Ab-(001)-02017 Anti-CYP1A1 细胞色素P450 1A1抗体 ,英文名: Anti-CYP1A1 ,规格: 0.2ml
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Ab-(001)-02019 Anti-CYP11A1/P450SCC 细胞色素P450 11A1抗体 ,英文名: Anti-CYP11A1/P450SCC ,规格: 0.2ml
Ab-(001)-02020 Anti-CYP2C9 细胞色素P450 2C9抗体 ,英文名: Anti-CYP2C9 ,规格: 0.2ml
Ab-(001)-02021 Anti-CYP3A4 细胞色素P450 3A4抗体 ,英文名: Anti-CYP3A4 ,规格: 0.2ml
Ab-(001)-02022 Anti-CYP2D6 细胞色素P450 2D6抗体 ,英文名: Anti-CYP2D6 ,规格: 0.2ml
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Ab-(001)-02031 Anti-Phospho-Dab1 (Tyr220) 磷酸化Disabled 1抗体 ,英文名: Anti-Phospho-Dab1 ,规格: 0.1ml
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