供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-0079 |
CAS号: | 详见产品说明书 |
磷酸化活化复制因子2抗体
〖别名〗ATF2 (phospho S480); p-ATF2 (phospho S480); p-ATF2 (phospho Ser480); ATF2(Phospho-Ser480); CREB 2; HB 16; Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response Element Binding Protein 2; cAMP response element binding protein CRE BP1; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE BP1; CRE-BP; CREB 2; CREB2; CREBP1; Cyclic AMP dependent transcription factor ATF 2; Cyclic AMP-responsive; ATF2_HUMAN.
〖浓度〗1mg/1ml
〖规格〗0.1ml/100μg
〖抗体来源〗磷酸化活化复制因子2抗体Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗Human, Mouse
〖产品类型〗一抗 磷酸化抗体
〖研究领域〗细胞生物 神经生物学 转运蛋白 表观遗传学
〖蛋白分子量〗predicted molecular weight: 45kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated synthesised phosphopeptide derived from human ATF2 around the phosphorylation site of Ser480
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
〖产品应用〗WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.
Function : Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex.
Subunit : Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.
Subcellular Location : Nucleus.
Tissue Specificity : Abundant expression seen in the brain.
Post-translational modifications : Phosphorylation of Thr-69 and Thr-71 by MAPK14 causes increased transcriptional activity. Also phosphorylated and activated by JNK.
Similarity : Belongs to the bZIP family. ATF subfamily.
Contains 1 bZIP domain.
Contains 1 C2H2-type zinc finger.
Database links : UniProtKB/Swiss-Prot: P15336.4
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Ab-(001)-04018 Anti-TRH 促甲状腺素释放激素抗体 ,英文名: Anti-TRH ,规格: 0.2ml
Ab-(001)-04019 Anti-Tau protein 微管相关蛋白抗体 ,英文名: Anti-Tau ,规格: 0.1ml
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Ab-(001)-04021 Anti-phospho-Tau protein (Ser396) 磷酸化微管相关蛋白抗体 ,英文名: Anti-phospho-Tau ,规格: 0.1ml
Ab-(001)-04022 Anti-phospho-Tau protein (Ser422) 磷酸化微管相关蛋白抗体 ,英文名: Anti-phospho-Tau ,规格: 0.1ml
Ab-(001)-04023 Anti-MAP2 微管相关蛋白2抗体 ,英文名: Anti-MAP2 ,规格: 0.1ml
Ab-(001)-04024 Anti-Phospho-MAP2 (Ser136) 磷酸化微管相关蛋白2抗体 ,英文名: Anti-Phospho-MAP2 ,规格: 0.1ml
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Ab-(001)-04026 Anti-MAP1A 微管相关蛋白1A抗体 ,英文名: Anti-MAP1A ,规格: 0.1ml
Ab-(001)-04027 Anti-Talin 踝蛋白抗体 ,英文名: Anti-Talin ,规格: 0.1ml
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Ab-(001)-04032 Anti-TBX18 转录因子Tbx18抗体 ,英文名: Anti-TBX18 ,规格: 0.2ml
Ab-(001)-04033 Anti-TCF7L2 转录因子7类似物2抗体 ,英文名: Anti-TCF7L2 ,规格: 0.1ml
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Ab-(001)-04036 Anti-TDP-43 Tar DNA 结合蛋白43抗体 ,英文名: Anti-TDP-43 ,规格: 0.1ml
Ab-(001)-04037 Anti-PHLDA1/TDAG51 T淋巴细胞凋亡相关蛋白TDAG51抗体 ,英文名: Anti-PHLDA1/TDAG51 ,规格: 0.2ml
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Ab-(001)-04066 Anti-phospho-p38MAPK/MAPK14 (pThr180/pTyr182) 磷酸化p38MAPK抗体 ,英文名: Anti-phospho-p38MAPK/MAPK14 ,规格: 0.1ml
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