供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-0095 |
CAS号: | 详见产品说明书 |
磷酸化腺苷三磷酸结合盒转运体A1抗体
〖别名〗ABCA1 (phospho S2054); p-ABCA1 (phospho S2054); ATP binding cassette transporter A1; ABC 1; ABC Transporter 1; ABC1; ABCA 1; ABCA1; ATP binding Cassette 1; ATP binding cassette sub family A ABC1 member 1; ATP binding cassette sub family A member 1; ATP binding cassette sub-family A member 1; ATP binding Cassette Transporter 1; ATP-binding Cassette 1; ATP-binding Cassette Transporter 1; CERP; Cholesterol Efflux Regulatory Protein; FLJ14958; HDLDT1; Membrane bound; MGC164864; MGC165011; TD; TGD; ABCA1_HUMAN.
〖浓度〗1mg/1ml
〖规格〗0.1ml/100μg
〖抗体来源〗磷酸化腺苷三磷酸结合盒转运体A1抗体Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗Human, Mouse, Rat, Dog, Pig
〖产品类型〗一抗 磷酸化抗体
〖研究领域〗肿瘤 细胞生物 信号转导 新陈代谢
〖蛋白分子量〗predicted molecular weight: 254kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated synthesised phosphopeptide derived from human ABCA1 around the phosphorylation site of Ser2054
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
〖产品应用〗ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
Function : cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
Subunit : Interacts with MEGF10.
Subcellular Location : Membrane; Multi-pass membrane protein.
Tissue Specificity : Widely expressed, but most abundant in macrophages.
Post-translational modifications : Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylation by DHHC8 is essential for membrane localization.
DISEASE : Defects in ABCA1 are a cause of high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness.
Defects in ABCA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). HDLD2 is inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.
Similarity : Belongs to the ABC transporter superfamily. ABCA family.
Contains 2 ABC transporter domains.
Database links : UniProtKB/Swiss-Prot: O95477.3
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Ab-(001)-04832 Anti-CD43/SPN/FITC 荧光素标记CD43抗体IgG ,英文名: Anti-CD43/SPN/FITC ,规格: 0.2ml
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Ab-(001)-04834 Anti-CD44v4 /FITC 荧光素标记兔抗人、大、小鼠CD44V4抗体IgG ,英文名: Anti-CD44v4 ,规格: 0.2ml
Ab-(001)-04835 Anti-CD44v5 /FITC 荧光素标记兔抗人、大、小鼠CD44V5抗体IgG ,英文名: Anti-CD44v5 ,规格: 0.2ml
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Ab-(001)-04837 Anti-CD44v7 /FITC 荧光素标记兔抗人、大、小鼠CD44V7抗体IgG ,英文名: Anti-CD44v7 ,规格: 0.2ml
Ab-(001)-04838 Anti-CD45(LCA)/FITC 荧光素标记CD45(白细胞共同抗原)抗体 ,英文名: Anti-CD45 ,规格: 0.2ml
Ab-(001)-04839 Anti-CD45/RBITC 红色荧光素罗丹明标记CD45抗体 IgG ,英文名: Anti-CD45/RBITC ,规格: 0.2ml
Ab-(001)-04840 Anti-CD45RO/FITC 荧光素标记CD45RO抗体IgG ,英文名: Anti-CD45RO/FITC ,规格: 0.2ml
Ab-(001)-04841 Anti-CD46/MCP /FITC 荧光素标记膜辅蛋白/内源性辅助因子活性蛋白抗体(人)IgG ,英文名: Anti-CD46/MCP ,规格: 0.2ml
Ab-(001)-04842 Anti-CD46/MCP /FITC 荧光素标记膜辅蛋白/内源性辅助因子活性蛋白抗体IgG ,英文名: Anti-CD46/MCP ,规格: 0.2ml
Ab-(001)-04843 Anti-CA125/Biotin 生物素标记兔抗人CA125抗原抗体IgG ,英文名: Anti-CA125/Biotin ,规格: 0.2ml
Ab-(001)-04844 Anti-CD48/SLAMF2/FITC 荧光素标记CD48抗体IgG ,英文名: Anti-CD48/SLAMF2/FITC ,规格: 0.2ml
Ab-(001)-04845 Anti-CD44/PE 荧光素PE标记CD44抗体IgG ,英文名: Anti-CD44/PE ,规格: 0.2ml
Ab-(001)-04846 Anti-CD45/PE 荧光素PE标记兔抗人、小鼠CD45抗体IgG ,英文名: Anti-CD45/PE ,规格: 0.2ml
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Ab-(001)-04848 Anti-CD55/DAF/FITC 荧光素标记衰变加速因子CD55抗体IgG ,英文名: Anti-CD55/DAF/FITC ,规格: 0.2ml
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Ab-(001)-04850 Anti-CD56/NCAM1/FITC 荧光素标记神经细胞粘附分子1抗体IgG ,英文名: Anti-CD56/NCAM1/FITC ,规格: 0.2ml
Ab-(001)-04851 Anti-CD57/FITC 荧光素标记抗CD57抗体IgG ,英文名: Anti-CD57/FITC ,规格: 0.2ml
Ab-(001)-04852 Anti-CD58/LFA-3/FITC 荧光素标记淋巴细胞功能相关抗原-3抗体IgG ,英文名: Anti-CD58/LFA-3/FITC ,规格: 0.2ml
Ab-(001)-04853 Anti-CD59/FITC 荧光素标记反应性溶血膜抑制蛋白抗体IgG ,英文名: Anti-CD59/FITC ,规格: 0.2ml
Ab-(001)-04854 Anti-CD62L/FITC 荧光素标记L选择素抗体IgG ,英文名: Anti-CD62L/FITC ,规格: 0.2ml
Ab-(001)-04855 Anti-CD63/MLA1 /FITC 荧光素标记抗溶酶体膜糖蛋白抗体IgG ,英文名: Anti-CD63/MLA1 ,规格: 0.2ml
Ab-(001)-04856 Anti-CD63/MLA1 /RBITC 红色荧光素罗丹明(RBITC)标记抗溶酶体膜糖蛋白抗体IgG ,英文名: Anti-CD63/MLA1 ,规格: 0.2ml
Ab-(001)-04857 Anti-CD66a/Cea-1/CEACAM1/FITC 荧光素标记癌胚抗原相关细胞粘附分子1抗体IgG ,英文名: Anti-CD66a/Cea-1/CEACAM1/FITC ,规格: 0.2ml
Ab-(001)-04858 Anti-CD67/CEAcam8/FITC 荧光素标记整合素样癌胚抗原相关细胞粘附分子8抗体IgG ,英文名: Anti-CD67/CEAcam8/FITC ,规格: 0.2ml
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Ab-(001)-04862 Anti-CD69/CLEC2C/AIM/FITC 荧光素标记活化诱导分子CD69抗体IgG ,英文名: Anti-CD69/CLEC2C/AIM/FITC ,规格: 0.2ml
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Ab-(001)-04865 Anti-B7-1/CD80 /FITC 荧光素标记抗刺激分子B7-1蛋白抗体IgG ,英文名: Anti-B7-1/CD80 ,规格: 0.2ml
Ab-(001)-04866 Anti-CD80/B7-1/FITC 荧光素标记刺激分子B7-1蛋白抗体IgG ,英文名: Anti-CD80/B7-1/FITC ,规格: 0.2ml
Ab-(001)-04867 Anti-CD82/KAI1/FITC 荧光素标记肿瘤转移抑制蛋白1抗体IgG ,英文名: Anti-CD82/KAI1/FITC ,规格: 0.2ml
Ab-(001)-04868 Anti-CD83/Cell surface protein HB15/FITC 荧光素标记CD83抗体IgG ,英文名: Anti-CD83/Cell ,规格: 0.2ml
Ab-(001)-04869 Anti-CD84/SLAMF5/FITC 荧光素标记CD84抗体IgG ,英文名: Anti-CD84/SLAMF5/FITC ,规格: 0.2ml
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Ab-(001)-04873 Anti-ICAM-2/CD102 /FITC 荧光素标记细胞间粘附分子-2抗体IgG ,英文名: Anti-ICAM-2/CD102 ,规格: 0.2ml
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Ab-(001)-04875 Anti-CD105/Endoglin/TGF- Beta receptor /RBITC 红色荧光素罗丹明(RBITC)标记CD105/转化生长因子β受体抗体IgG ,英文名: Anti-CD105/Endoglin/TGF- ,规格: 0.2ml
Ab-(001)-04876 Anti-CD107a/LAMP-1/FITC 荧光素标记溶酶体相关膜蛋白1抗体IgG ,英文名: Anti-CD107a/LAMP-1/FITC ,磷酸化腺苷三磷酸结合盒转运体A1抗体规格: 0.2ml
Ab-(001)-04877 Anti-CD107a/LAMP-1/PE 荧光素PE标记溶酶体相关膜蛋白1抗体IgG ,英文名: Anti-CD107a/LAMP-1/PE ,规格: 0.2ml
Ab-(001)-04878 Anti-nectin 2/CD112/FITC 荧光素标记细胞黏附分子CD112抗体IgG ,英文名: Anti-nectin ,规格: 0.2ml
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