供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-0163 |
CAS号: | 详见产品说明书 |
有丝分裂激酶B抗体
〖别名〗AURKC; AIE2; AIK3; AurC; AURKC; Aurora C; Aurora/Ipl1 related kinase 3; IPL-1; Aurora/Ipl1/Eg2 protein 2; EC 2.7.11.1; Serine threonine protein kinase 13; STK13; AURKC_HUMAN.
〖浓度〗1mg/1ml
〖规格〗0.2ml/200μg
〖抗体来源〗Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗有丝分裂激酶B抗体Human, Mouse, Rat, Pig, Cow, Horse, Rabbit
〖产品类型〗一抗
〖研究领域〗细胞生物 神经生物学 信号转导 细胞周期蛋白 激酶和磷酸酶
〖蛋白分子量〗predicted molecular weight: 36kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated synthetic peptide derived from human Aurora C C-terminus
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
〖产品应用〗WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.
Function : Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Subunit : Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1.
Subcellular Location : Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.
Tissue Specificity : Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.
DISEASE : Spermatogenic failure 5 (SPGF5) [MIM:243060]: An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity : Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Contains 1 protein kinase domain.
Database links : UniProtKB/Swiss-Prot: Q9UQB9.1
细胞的有丝分裂是生物体最基本的生命活动过程,能将复制的基因组精确地分配到下一代子细胞中,在长期的生物进化过程中,生物体形成了一整套完善的监测机制以确保遗传物质精确地分配到子细胞中。 Aurora激酶(极光激酶)是细胞有丝分裂调控网络中的一类重要的丝氨酸/苏氨酸激酶,Aurora酪氨酸激酶B也是丝氨酸/苏氨酸激酶家族成员之一,目前分为aurora A,B及C。
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Ab-(001)-07974 DVL1 (dishevelled 1) 蓬乱蛋白1 ,英文名: DVL1 ,规格: 0.5mg
Ab-(001)-07975 Dynamin 2(Anti-Human Dynamin-2 ) 鸟苷三磷酸酶-发动蛋白2抗体 ,英文名: Dynamin ,规格: 0.5mg
Ab-(001)-07976 Nadrin peptide 发育调节蛋白多肽抗原 ,英文名: Nadrin ,规格: 0.5mg
Ab-(001)-07977 E2F1 转录因子E2F-1 ,英文名: E2F1 ,规格: 0.5mg
Ab-(001)-07978 E2F2 转录因子E2F-2抗原 ,英文名: E2F2 ,规格: 0.5mg
Ab-(001)-07979 E2F4 转录因子E2F-4抗原 ,英文名: E2F4 ,规格: 0.5mg
Ab-(001)-07980 E2F6 转录因子E2F-6抗原 ,英文名: E2F6 ,规格: 0.5mg
Ab-(001)-07981 E2 tag E2 tag多肽抗原 ,英文名: E2 ,规格: 0.5mg
Ab-(001)-07982 EAAT3(Excitatory amino acid transporters 3) 胶质细胞谷氨酸运载蛋白3抗原 ,英文名: EAAT3 ,规格: 0.5mg
Ab-(001)-07983 EBNA-3 (EpsteinBarr nuclear Anti-gens 3) EB病毒编码核蛋白-3(抗原) ,英文名: EBNA-3 ,规格: 0.5mg
Ab-(001)-07984 ECE1(Endothelin Converting Enzyme 1) 内皮素转化酶1抗原 ,英文名: ECE1 ,规格: 0.5mg
Ab-(001)-07985 ECE2(Endothelin Converting Enzyme 2) 内皮素转化酶2抗原 ,英文名: ECE2 ,规格: 0.5mg
Ab-(001)-07986 ECP(eosinophil cationic protein)mouse rat 嗜酸性粒细胞阳离子蛋白抗原 ,英文名: ECP ,规格: 0.5mg
Ab-(001)-07987 ED-1 (Ectodermal Dysplasia 1) 外胚层发育不良抗原 ,英文名: ED-1 ,规格: 0.5mg
Ab-(001)-07988 rhEGF(rh-Epidermal growth factor) 重组人表皮生长因子 ,英文名: rhEGF ,规格: 100ug
Ab-(001)-07989 EGF(Epidermal growth factor)rat 重组表皮生长因子抗原(大鼠) ,英文名: EGF ,规格: 0.5mg
Ab-(001)-07990 EGFL7(EGF-like domain containing protein 7) 类表皮生长因子域7抗原 ,英文名: EGFL7 ,规格: 0.5mg
Ab-(001)-07991 Egr-1(Early growth response 1) 早期反应基因-1/应急反应生长基因1抗原 ,英文名: Egr-1 ,规格: 0.5mg
Ab-(001)-07992 phospho-eIF4E(pSer209)(phospho-Eukaryotic translation initiation factor 4E) 磷酸化eIF-4E(Ser209)抗原 ,英文名: phospho-eIF4E ,规格: 0.5mg
Ab-(001)-07993 ELK1 细胞转录因子ELK1抗原 ,英文名: ELK1 ,规格: 0.5mg
Ab-(001)-07994 Elastin 弹性蛋白抗原 ,英文名: Elastin ,规格: 0.5mg
Ab-(001)-07995 ELAVL1/HuR peptide ELAVL1/HuR多肽抗原 ,英文名: ELAVL1/HuR ,规格: 0.5mg
Ab-(001)-07996 Emp1 (epithelial membrane protein 1) 表皮膜蛋白1抗原 ,英文名: Emp1 ,规格: 0.5ml
Ab-(001)-07997 sFRP-4(Secreted frizzled-related protein 4; Frizzled protein, human endometrium) 抗子宫内膜抗原 ,英文名: sFRP-4 ,规格: 0.5mg
Ab-(001)-07998 Endostatin 内皮抑素/内皮他丁抗原 ,英文名: Endostatin ,规格: 0.5mg
Ab-(001)-07999 EpCAM(Epithelial cell adhesion molecule) 上皮细胞粘附分子/表皮细胞粘附分子(多肽) ,英文名: EpCAM ,规格: 0.5mg
Ab-(001)-08000 EpCAM/CD326(Epithelial cell adhesion molecule) 上皮细胞粘附分子/表皮细胞粘附分子抗原 ,英文名: EpCAM/CD326 ,规格: 0.5mg
Ab-(001)-08001 E.coli O6 (Escherichia coli O6) E.coli O6大肠杆菌菌体蛋白 ,英文名: E.coli ,规格: 0.5mg
Ab-(001)-08002 EPEC/E.coli(enteropathogenic E.coli,EPEC) 普通大肠埃希菌菌体蛋白(非致病性) ,英文名: EPEC/E.coli ,规格: 0.5mg
Ab-(001)-08003 EphA1 R(Ephrin A1 Receptor) EphA1-R受体抗原 ,英文名: EphA1 ,规格: 0.5mg
Ab-(001)-08004 EPOR peptide 红细胞生成素受体抗原 ,英文名: EPOR ,规格: 0.5mg
Ab-(001)-08005 phospho-ERK1/MAPK-1/2(pThr183 + pTyr185) 磷酸化丝裂原活化蛋白激酶1/2抗原 ,英文名: phospho-ERK1/MAPK-1/2 ,规格: 0.5mg
Ab-(001)-08006 ERK(Extracellular signal-regulated kinase) 丝裂原活化蛋白激酶抗原 ,英文名: ERK ,规格: 0.5mg
Ab-(001)-08007 MAPK1/ERK3 (Mitogen-activated protein kinase 3; P44MAPK) 丝裂原活化蛋白激酶3抗原 ,英文名: MAPK1/ERK3 ,规格: 0.5mg
Ab-(001)-08008 MAPK4(Mitogen-activated protein kinase 4) 丝裂原活化蛋白激酶4抗原 ,英文名: MAPK4 ,规格: 0.5mg
Ab-(001)-08009 ER- Alpha(phospho-Ser167)peptide 人磷酸化雌激素受体α多肽抗原 ,英文名: ER- ,规格: 0.5mg
Ab-(001)-08010 ER- Alpha(phospho-Tyr537)peptide 磷酸化雌激素受体α抗原 ,英文名: ER- ,规格: 0.5mg
Ab-(001)-08011 ER- Alpha /ER alpha peptide 雌激素受体α抗原 ,英文名: ER- ,规格: 0.5mg
Ab-(001)-08012 ER- Alpha/ER alpha peptide 雌激素受体α抗原 ,英文名: ER- ,规格: 0.5mg
Ab-(001)-08013 ER- Beta (Estrogen receptor-beta) peptide 雌激素受体β抗原 ,英文名: ER- ,规格: 0.5mg
Ab-(001)-08014 ets1/E26 (E-twenty six 1) Ets转录因子家族ets1抗原 ,英文名: ets1/E26 ,规格: 0.5mg
Ab-(001)-08015 EV71(Human enterovirus 71)VP1 肠道病毒71型/手足口病病毒抗原 ,英文名: EV71 ,规格: 0.5mg
Ab-(001)-08016 EV71(Human enterovirus 71)VP1(CT) 肠道病毒71型/手足口病病毒抗原(C端) ,英文名: EV71 ,规格: 0.5mg
Ab-(001)-08017 ATEXPA10 peptide 植物扩张蛋白ATEXPA10(拟南芥)抗原 ,英文名: ATEXPA10 ,规格: 0.5mg
Ab-(001)-08018 Ezrin/Radixin 埃兹蛋白(多肽) ,英文名: Ezrin/Radixin ,规格: 0.5mg
Ab-(001)-08019 F1 operon positive regulatory protein(NT) 鼠疫耶尔森氏菌F1荚膜蛋白(N端多肽) ,英文名: F1 ,规格: 0.5mg
Ab-(001)-08020 F1 operon positive regulatory protein(CT) 鼠疫耶尔森氏菌F1荚膜蛋白(C端多肽) ,英文名: F1 ,规格: 0.5mg
Ab-(001)-08021 FABP(brain) (Fatty acid-binding protein brain) 脑型脂肪酸结合蛋白抗原 ,英文名: FABP ,有丝分裂激酶B抗体规格: 0.5mg
Ab-(001)-08022 FADD (Fas-associated protein with death domain) Fas死亡结构域相关蛋白抗原 ,英文名: FADD ,规格: 0.5mg
Ab-(001)-08023 FAK(Focaladhesin kinase) 粘着斑激酶抗原 ,英文名: FAK ,规格: 0.5mg
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