供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-0178 |
CAS号: | 详见产品说明书 |
磷酸化腺泡Acinus蛋白抗体
〖别名〗Acinus (phospho S1180); Acinus (phospho Ser1180); Acinus (phospho-S1180); Acinus (phospho-Ser1180); p-Acinus (Ser1180); ACIN 1; ACIN1; ACINU_HUMAN; Acinus; ACN; Apoptotic chromatin condensation inducer 1; Apoptotic chromatin condensation inducer in the nucleus; DKFZp667N107; fSAP152; functional spliceosome-associated protein 152; KIAA0670.
〖浓度〗1mg/1ml
〖规格〗0.1ml/100μg
〖抗体来源〗Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗Human, Mouse, Rat, Dog, Pig, Cow, Horse
〖产品类型〗磷酸化腺泡Acinus蛋白抗体一抗 磷酸化抗体
〖研究领域〗细胞生物 神经生物学 信号转导 细胞凋亡 转录调节因子
〖蛋白分子量〗predicted molecular weight: 148kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated Synthesised phosphopeptide derived from human Acinus around the phosphorylation site of Ser1180
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
〖产品应用〗IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗Chromatin condensation and nuclear fragmentation (CCNF) are the hallmarks of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by Caspase 3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated Acinus L (1341 amino acids), Acinus S (583 amino acids) and Acinus S' (614 amino acids)
Function : Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.
Subunit : Found in a mRNA splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3, EIF4A3, MAGOH, PNN, RBM8A, RNPS1, SAP18 and ALYREF/THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Interacts with API5. Interacts with SRPK2 in a phosphorylation-dependent manner.
Subcellular Location : Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.
Tissue Specificity : Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.
Post-translational modifications : Phosphorylation on Ser-1180 by SRPK2 up-regulates its stimulatory effect on cyclin A1.
Undergoes proteolytic cleavage; the processed form is active, contrary to the uncleaved form.
Similarity : Contains 1 SAP domain.
Database links : UniProtKB/Swiss-Prot: Q9UKV3.2
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Ab-(001)-08596 Measles virus protein(Plant2 derived measles virus hemagglutinin protein) 麻疹病毒红血球凝集素蛋白多肽 ,英文名: Measles ,规格: 0.5mg
Ab-(001)-08597 HMGB1 (High Mobility Group Box protein 1) 高迁移率族蛋白-1(抗原) ,英文名: HMGB1 ,规格: 0.5mg
Ab-(001)-08598 HSL(hormone-sensitive lipase) 荷尔蒙敏感脂肪酸(抗原) ,英文名: HSL ,规格: 0.5mg
Ab-(001)-08599 HSP-27(Heat Shock Protein 27) 热休克蛋白-27(抗原) ,英文名: HSP-27 ,规格: 0.5mg
Ab-(001)-08600 HSP-90Alpha(Heat Shock Protein 90Alpha ) 热休克蛋白90α(抗原) ,英文名: HSP-90Alpha ,规格: 0.5mg
Ab-(001)-08601 HSP-90 Beta (heat sock protein-90 Beta) 热休克蛋白-90β (抗原) ,英文名: HSP-90 ,规格: 0.5mg
Ab-(001)-08602 IASPP(inhibitory member of the ASPP family) 肿瘤细胞凋亡ASPP家族的另一个成员(抗原) ,英文名: IASPP ,规格: 0.5mg
Ab-(001)-08603 CD54 ICAM-1 (Intercellular dhesion molecule 1; CD54 Anti-gen;) 细胞间粘附分子-1(多肽抗原) ,英文名: CD54 ,规格: 0.5mg
Ab-(001)-08604 IL-1 Beta(Interleukin-1 Beta) 白介素1β(白细胞介素-1β)(多肽抗原) ,英文名: IL-1 ,规格: 0.5mg
Ab-(001)-08605 IL1RAPL1 (Interleukin 1 receptor accessory protein-like 1) 白介素受体相关蛋白样1前体蛋白(抗原) ,英文名: IL1RAPL1 ,规格: 0.5mg
Ab-(001)-08606 IL-6(Interleukin-6) 白介素6(白细胞介素-6)(多肽抗原) ,英文名: IL-6 ,规格: 0.5mg
Ab-(001)-08607 IL-10(Interleukin-10) 白介素10(白细胞介素-10)(抗原) ,英文名: IL-10 ,规格: 0.5mg
Ab-(001)-08608 IL-8 白介素8(白细胞介素-8)(抗原) ,英文名: IL-8 ,规格: 0.5mg
Ab-(001)-08609 Insulin Receptor(ISR) 胰岛素受体(抗原) ,英文名: Insulin ,规格: 0.5mg
Ab-(001)-08610 Integrin Alpha 4/ITGA4(Integrin alpha 4) 整合素-α(抗原) ,英文名: Integrin ,规格: 0.5ml
Ab-(001)-08611 LDL-R(Low-density lipoprotein receptor precursor) 低密度脂蛋白受体(抗原) ,英文名: LDL-R ,规格: 0.5mg
Ab-(001)-08612 Ki-67 Anti-gen Ki-67 Antigen(抗原) ,英文名: Ki-67 ,规格: 0.5mg
Ab-(001)-08613 Kiss-1(Metastasis-suppressor KiSS-1 precursor) 肿瘤转移抑制基因(抗原) ,英文名: Kiss-1 ,规格: 0.5mg
Ab-(001)-08614 Snake poison Protein 蛇毒蛋白 ,英文名: Snake ,规格: 0.5mg
Ab-(001)-08615 Snake poison Protein 蛇毒蛋白 ,英文名: Snake ,规格: 1mg
Ab-(001)-08616 Batroxobin Protein 蛇毒巴曲酶全蛋白 ,英文名: Batroxobin ,规格: 1mg
Ab-(001)-08617 Leptin 瘦素(抗原) ,英文名: Leptin ,规格: 0.5mg
Ab-(001)-08618 Lpin1 protein Lpin1 protein(抗原) ,英文名: Lpin1 ,规格: 0.5mg
Ab-(001)-08619 Lumbrokinase 蚯蚓纤溶酶(蚓激酶抗原) ,英文名: Lumbrokinase ,规格: 0.5mg
Ab-(001)-08620 Livin (Inhibitors of apoptosis proterins Livin) 一种新的凋亡抑制蛋白(抗原) ,英文名: Livin ,规格: 0.5mg
Ab-(001)-08621 p38 MAPK/MKK3/MAPKK14 丝裂原活化蛋白激酶p38(抗原) ,英文名: p38 ,规格: 0.5mg
Ab-(001)-08622 Metal ion transporter 拟南介金属离子转运蛋白(抗原) ,英文名: Metal ,规格: 0.5mg
Ab-(001)-08623 MADCAM-1 黏膜选址素(抗原) ,英文名: MADCAM-1 ,规格: 0.5mg
Ab-(001)-08624 MAG-a/b (Myelin associated glycoprotein; L / S -MAG;) 髓鞘相关糖蛋白a/b(抗原) ,英文名: MAG-a/b ,规格: 0.5mg
Ab-(001)-08625 MAG (Myelin associated glycoprotein; L-MAG;MAG-a ) 髓鞘相关糖蛋白(抗原) ,英文名: MAG ,规格: 0.5mg
Ab-(001)-08626 MAG-a (Myelin associated glycoprotein; L-MAG; ) 髓鞘相关糖蛋白-a(抗原) ,英文名: MAG-a ,规格: 0.5mg
Ab-(001)-08627 MMP-1(Mous ematrix metalloproteinases-1) 基质金属蛋白酶-1(小鼠抗原) ,英文名: MMP-1 ,规格: 0.5mg
Ab-(001)-08628 midnolin isoform Protein 1 中脑核仁蛋白1(抗原) ,英文名: midnolin ,规格: 0.5mg
Ab-(001)-08629 midnolin isoform Protein 2 中脑核仁蛋白2(抗原) ,英文名: midnolin ,规格: 0.5mg
Ab-(001)-08630 MICA(MHC class I polypeptide-related sequence A) 一种细胞应激分子抗原 ,英文名: MICA ,规格: 0.5mg
Ab-(001)-08631 MRP3(Multidrug Resistanec-Associated Protein 3) 多药耐药相关蛋白3(抗原) ,英文名: MRP3 ,规格: 0.5mg
Ab-(001)-08632 MRP1(Multidrug Resistanec-Associated Protein 1) 多药耐药相关蛋白1(抗原) ,英文名: MRP1 ,规格: 0.5mg
Ab-(001)-08633 LRP/MVP (Lung resistance related protein) 肺耐药相关蛋白(抗原) ,英文名: LRP/MVP ,规格: 0.5mg
Ab-(001)-08634 MSLN(mesothelin) 间皮素(多肽抗原) ,英文名: MSLN ,规格: 0.5mg
Ab-(001)-08635 MSH2 (mutS homolog 2) MSH2抗原 ,英文名: MSH2 ,磷酸化腺泡Acinus蛋白抗体规格: 0.5mg
Ab-(001)-08636 NKR(Neuromedin B Receptor) 神经激肽B受体(抗原) ,英文名: NKR ,规格: 0.5mg
Ab-(001)-08637 NF-L(Neurofilament triplet L) 低分子量神经丝蛋白(抗原) ,英文名: NF-L ,规格: 0.5mg
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