供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-0179 |
CAS号: | 详见产品说明书 |
磷酸化肾上腺素能受体β2抗体
〖别名〗β2-adrenergic receptor; ADRB2; ADRB2R; ADRBR; Adrenergic beta 2 receptor surface; B2AR; BAR; beta 2 adrenoceptor; Beta 2 adrenoreceptor; BETA2AR; Catecholamine receptor; beta2-adrenergic receptor; ADRB2_HUMAN.
〖浓度〗1mg/1ml
〖规格〗0.1ml/100μg
〖抗体来源〗Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗Human, Mouse, Rat, Dog, Horse, Sheep
〖产品类型〗磷酸化肾上腺素能受体β2抗体一抗 磷酸化抗体
〖研究领域〗神经生物学 细胞膜受体 内分泌病
〖蛋白分子量〗predicted molecular weight: 46kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated Synthesised phosphopeptide derived from human ADRB2 around the phosphorylation site of Ser346
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
〖产品应用〗WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗Beta 2 Adrenergic Receptor is a member of the G protein coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L type calcium channel Ca(V)1.2. This receptor channel complex also contains a G protein, an adenylyl cyclase, cAMP dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.
Function : Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Subunit : Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination.
Subcellular Location : Cell membrane; Multi-pass membrane protein.
Post-translational modifications : Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.
Phosphorylated by PKA and BARK upon agonist stimulation, which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK. Phosphorylated upon DNA damage, probably by ATM or ATR.
Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor.
Polyubiquitinated. Agonist-induced ubiquitination leads to sort internalized receptors to the lysosomes for degradation. Deubiquitination by USP20 and USP33, leads to ADRB2 recycling and resensitization after prolonged agonist stimulation. USP20 and USP33 are constitutively associated and are dissociated immediately after agonist stimulation. Ubiquitination by the VHL-E3 ligase complex is oxygen-dependent.
Hydroxylation by EGLN3 occurs only under normoxia and increases the interaction with VHL and the subsequent ubiquitination and degradation of ADRB2.
Similarity : Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
Database links : UniProtKB/Swiss-Prot: P07550.3
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Ab-(001)-08638 NF-M (Neurofilament triplet M) 中分子量神经丝蛋白(抗原) ,英文名: NF-M ,规格: 0.5mg
Ab-(001)-08639 NF-H(Neurofilament triplet H) 高分子量神经丝蛋白(抗原) ,英文名: NF-H ,规格: 0.5mg
Ab-(001)-08640 NIS(Na+/I-symporter;NIS) 钠碘转运体蛋白(多肽抗原) ,英文名: NIS ,规格: 0.5mg
Ab-(001)-08641 NFKBp65(p65 NF-kappa B;p65NFKB) 细胞核因子或称k基因结合核因子(多肽抗原) ,英文名: NFKBp65 ,规格: 0.5mg
Ab-(001)-08642 NR2A (Glutamate receptor2A) 谷氨酸受体(N端抗原) ,英文名: NR2A ,规格: 0.5mg
Ab-(001)-08643 NRP-1(neuropilin-1) 神经纤毛蛋白-1(抗原) ,英文名: NRP-1 ,规格: 0.5mg
Ab-(001)-08644 NRP-2(neuropilin-2) 神经纤毛蛋白-2(抗原) ,英文名: NRP-2 ,规格: 0.5mg
Ab-(001)-08645 NSBP1(Nucleosome-binding protein 1) 核小体结合蛋白1(抗原) ,英文名: NSBP1 ,规格: 0.5mg
Ab-(001)-08646 NTP,Neurual thread protein 神经丝蛋白(抗原) ,英文名: NTP,Neurual ,规格: 0.5mg
Ab-(001)-08647 OAT-1 (Organic anion transporter 1)human 阴离子转运蛋白-1(人源) ,英文名: OAT-1 ,规格: 0.5mg
Ab-(001)-08648 OAT-1 (Organic anion transporter 1)mouse、rat 阴离子转运蛋白-1(大、小鼠同源:人源见bs-0606P) ,英文名: OAT-1 ,规格: 0.5mg
Ab-(001)-08649 OAT-3(Organic anion transporter 3) 阴离子转运蛋白-3(抗原) ,英文名: OAT-3 ,规格: 0.5mg
Ab-(001)-08650 galectin 9 半乳糖凝集素9(抗原) ,英文名: galectin ,规格: 0.5mg
Ab-(001)-08651 OPN(osteopontin) 骨桥蛋白(抗原) ,英文名: OPN ,规格: 0.5mg
Ab-(001)-08652 P16/CDKN2A (Cyclin-dependent kinase inhibitor-2A) 抑癌基因p16(抗原) ,英文名: P16/CDKN2A ,规格: 0.5mg
Ab-(001)-08653 p21/WAF1/CIP1 p21 核分裂抑制因子之一(抗原) ,英文名: p21/WAF1/CIP1 ,规格: 0.5mg
Ab-(001)-08654 p27 (cyclin-dependent kinase inhibitor 1B) p27(抗原) ,英文名: p27 ,规格: 0.5mg
Ab-(001)-08655 P63 protein P63 肿瘤抑制基因(抗原) ,英文名: P63 ,规格: 0.5mg
Ab-(001)-08656 OPG(Osteoprotegerin) 护骨素(多肽抗原) ,英文名: OPG ,规格: 0.5mg
Ab-(001)-08657 OPGL (Osteoprotegerin ligand) 骨保护蛋白配体(抗原) ,英文名: OPGL ,规格: 0.5mg
Ab-(001)-08658 P311 protein 增生性瘢痕相关蛋白(抗原) ,英文名: P311 ,规格: 0.5mg
Ab-(001)-08659 PARP(poly ADP-ribose polymerase) 多腺苷二磷酸多聚酶抗原 ,英文名: PARP ,规格: 0.5mg
Ab-(001)-08660 Visfatin-1 (PBEF1)(NT) Human 内脂素/内脏脂肪素(人:N端多肽)、内脏脂肪素、 又称:前B细胞克隆增强因子、内肥素、腹脂素 ,英文名: Visfatin-1 ,规格: 0.5mg
Ab-(001)-08661 Visfatin-1 (PBEF1)(NT) hu、 mo、 rat、MK 内脂素/内脏脂肪素(人、大、小鼠、猴同源:N端多肽)、内脏脂肪素、前B细胞克隆增强因子、内肥素、腹脂素 ,英文名: Visfatin-1 ,规格: 0.5mg
Ab-(001)-08662 Visfatin-2(CT)hu、mo、rat、MK 内脂素/内脏脂肪素(抗人、大、小鼠、猴:N端多肽)前B细胞克隆增强因子、内肥素、腹脂素 ,英文名: Visfatin-2 ,规格: 0.5mg
Ab-(001)-08663 PEDF (pigment epithelium-derived factor) 色素上皮源性因子(多肽抗原) ,英文名: PEDF ,规格: 0.5mg
Ab-(001)-08664 PAP2c (Phosphatidic acid phosphatase 2c) 磷脂酸磷酸酶2C(抗原) ,英文名: PAP2c ,规格: 0.5mg
Ab-(001)-08665 PEPT1 (Peptide-transporters 1) 肠道肽转运蛋白(小肽转运蛋白)多肽 ,英文名: PEPT1 ,规格: 0.5mg
Ab-(001)-08666 PTEN/MMAC1 一种肿瘤抑制基因抗原 ,英文名: PTEN/MMAC1 ,规格: 0.5mg
Ab-(001)-08667 PIBF(progesterone induced blocking factor) 孕激素诱导阻断因子(抗原) ,英文名: PIBF ,磷酸化肾上腺素能受体β2抗体规格: 0.5mg
Ab-(001)-08668 PIWIL1(piwi-like 1) piwi 样1蛋白(抗原) ,英文名: PIWIL1 ,规格: 0.5mg
Ab-(001)-08669 PPAR Gamma (peroxisome proliferator-activated receptor-gamma) 过氧化酶活化增生受体γ(抗原) ,英文名: PPAR ,规格: 0.5mg
Ab-(001)-08670 PP2Ac 蛋白磷酸酶4(抗原) ,英文名: PP2Ac ,规格: 0.5mg
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