供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-0184 |
CAS号: | 详见产品说明书 |
磷酸化细胞凋亡信号调节激酶1抗体
〖别名〗ASK1 (phospho S966); p-ASK1 (phospho S966); ASK1(Phospho-Ser966); Mitogen-activated protein kinase kinase kinase 5; MAPK/ERK kinase kinase 5; MEK kinase 5; Short=MEKK 5; Apoptosis signal-regulating kinase 1; ASK-1; MAP3K5; ASK1; MAPKKK5; MEKK5.
〖浓度〗1mg/1ml
〖规格〗0.1ml/100μg
〖抗体来源〗Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗Human, Mouse, Rat, Chicken, Dog, Horse
〖产品类型〗磷酸化细胞凋亡信号调节激酶1抗体一抗 磷酸化抗体
〖研究领域〗肿瘤 细胞生物 信号转导 细胞凋亡 激酶和磷酸酶
〖蛋白分子量〗predicted molecular weight: 152kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated Synthesised phosphopeptide derived from human ASK1 around the phosphorylation site of Ser966
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
〖产品应用〗WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
Function : Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.
Tissue Specificity : Abundantly expressed in heart and pancreas.
Post-translational modifications : Dephosphorylated and activated by PGAM5.
Similarity : Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family.
MAP kinase kinase kinase subfamily.
本公司产品现货供应,货期短,质量可靠。仅用于科研实验不应用于临床。我们用专业的态度,一流的服务,全程实验指导,让你的数据不在成为实验奇谈。选择优质的磷酸化细胞凋亡信号调节激酶1抗体,你的小伙伴都会惊呆的。本公司专业供应各种进口、国产一抗及二抗。代理品牌有R&D、Santa Cruz、Bipec、Millipore等国际知名品牌,品种多达7000多种。让你的科研之路不再布满荆棘。
我们还可以为客户提供产品说明书。磷酸化细胞凋亡信号调节激酶1抗体拥有高纯度、高效价、高特异性的特点,可以应用于多种实验。免费送货上门,为您大大节省了时间和金钱。
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