供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-0217 |
CAS号: | 详见产品说明书 |
水通道蛋白-2抗体
〖别名〗ADH water channel; AQP 2; AQP CD; AQP2; AQPCD; Aquaporin 2 collecting duct; Aquaporin CD; Aquaporin2; Aquaporine 2; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; WCH CD; WCHCD; AQP2_HUMAN.
〖浓度〗1mg/1ml
〖规格〗0.1ml/100μg 0.2ml/200μg
〖抗体来源〗Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗水通道蛋白-2抗体Human, Mouse, Rat, Dog
〖产品类型〗一抗
〖研究领域〗免疫学 信号转导 通道蛋白
〖蛋白分子量〗predicted molecular weight: 30kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated synthetic peptide derived from human AQP2.
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
〖产品应用〗WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant, and recessive forms of nephrogenic diabetes insipidus.
Function : Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Subcellular Location : Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
Tissue Specificity : Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family.
Post-translational modifications : Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.
DISEASE : Defects in AQP2 are the cause of diabetes insipidus nephrogenic autosomal (ANDI) [MIM:125800]; also known as diabetes insipidus nephrogenic type 2. ANDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Inheritance can be autosomal dominant or recessive.
Similarity : Belongs to the MIP/aquaporin (TC 1.A.8) family.
通道蛋白(Channel Protein)水通道蛋白-2特异地存在于肾脏集合管,受血管加压素调节。有研究证明,AQP2(水通道蛋白-2)在糖尿病肾脏集合管表达增强。在1型糖尿病动物模型的水转运中尤其有意义。研究认为:AQP-2 奠定了糖尿病大鼠肾脏对水重吸收的基础,而且发现1型糖尿病病人的 AQP-2随血糖控制而减少。
本公司产品现货供应,货期短,质量可靠。仅用于科研实验不应用于临床。我们用专业的态度,一流的服务,全程实验指导,让你的数据不在成为实验奇谈。选择优质的水通道蛋白-2抗体,你的小伙伴都会惊呆的。本公司专业供应各种进口、国产一抗及二抗。代理品牌有R&D、Santa Cruz、Bipec、Millipore等国际知名品牌,品种多达7000多种。让你的科研之路不再布满荆棘。
我们还可以为客户提供产品说明书。水通道蛋白-2抗体拥有高纯度、高效价、高特异性的特点,可以应用于多种实验。免费送货上门,为您大大节省了时间和金钱。
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