供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-5043 |
CAS号: | 详见产品说明书 |
泛素蛋白连接酶E2抗体
〖别名〗E2 25K; E2(25K); HIP-2; Huntingtin interacting protein 2; Huntingtin-interacting protein 2; HYPG; LIG; UBC1; UBE2K; UBE2K_HUMAN; Ubiquitin carrier protein; Ubiquitin conjugating enzyme E2 25 kDa; Ubiquitin conjugating enzyme E2-25 kDa; ubiquitin conjugating enzyme E2K; ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast); Ubiquitin protein ligase; Ubiquitin-conjugating enzyme E2 K; Ubiquitin-conjugating enzyme E2(25K); Ubiquitin-conjugating enzyme E2-25 kDa; Ubiquitin-conjugating enzyme E2-25K; Ubiquitin-protein ligase.
〖浓度〗1mg/1ml
〖规格〗0.2ml/200μg
〖抗体来源〗Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗泛素蛋白连接酶E2抗体Human, Mouse, Chicken, Dog, Pig, Cow, Rabbit
〖产品类型〗一抗
〖研究领域〗细胞生物 免疫学 神经生物学 信号转导 表观遗传学
〖蛋白分子量〗predicted molecular weight: 24kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated synthetic peptide derived from human HIP2
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
〖产品应用〗WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
Subcellular Location : Cytoplasm.
Tissue Specificity : Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem.
Similarity : Belongs to the ubiquitin-conjugating enzyme family.
Contains 1 UBA domain.
做过实验的亲们都知道泛素蛋白连接酶E2抗体反应规律,仔细观察我们会发现当抗原第一次进入机体时,需经一定的潜伏期才能产生抗体,且抗体产生的量也不多,在体内维持的时间也较短。当相同抗原第二次进入机体后,开始时,由于原有抗体中的一部分与再次进入的抗原结合,可使原有抗体量略为降低。随后,抗体效价迅速大量增加,可比初次反应产生的多几倍到几十倍,在体内留存的时间亦较长。因此得出由抗原刺激机体产生的抗体,经过一定时间后可逐渐消失。此时若再次接触抗原,可使已消失的抗体快速上升。如再次刺激机体的抗原与初次相同,则称为特异性回忆反应;若与初次反应不同,则称为非特异性回忆反应。
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Ab-(010)-13720 抗CD38抗体(小鼠、大鼠) ,规格: 0.1ml ,英文名: Anti-CD38(mouse, rat)
Ab-(010)-13721 CD34抗体(细胞表面的唾液粘蛋白)C端蛋白多肽 ,规格: 0.1ml ,英文名: Anti-CD34(C-term)
Ab-(010)-13722 CD34抗体(细胞表面的唾液粘蛋白) ,规格: 0.1ml ,英文名: Anti-CD34
Ab-(010)-13723 CD33抗体(大、小鼠) ,规格: 0.1ml ,英文名: Anti-CD33/Siglec-3(mouse ret)
Ab-(010)-13724 CD33抗体(人) ,规格: 0.1ml ,英文名: Anti-CD33(human)
Ab-(010)-13725 CD3抗体 ,规格: 0.1ml ,英文名: Anti-CD3
Ab-(010)-13726 B和T淋巴细胞衰减蛋白抗体 ,规格: 0.1ml ,英文名: Anti-CD272/BTLA(B and T lymphocyte attenuator)
Ab-(010)-13727 CD122/白介素2受体β链抗体 ,规格: 0.1ml ,英文名: Anti-CD122/IL-2RB(Imterleukm-2 Receptor beta)
Ab-(010)-13728 CD25/白介素2受体a链抗体 ,规格: 0.1ml ,英文名: Anti-CD25/IL-2RA(Imterleukm-2 Receptor alpha)
Ab-(010)-13729 CD24抗体 ,规格: 0.1ml ,英文名: Anti-CD24
Ab-(010)-13730 抗B淋巴细胞粘附分子CD22抗体 ,规格: 0.1ml ,英文名: Anti-CD22/fpc1/blcam(B lymphocyte cell adhesion molecule)
Ab-(010)-13731 CD17抗体 ,规格: 0.1ml ,英文名: Anti-CD17
Ab-(010)-13732 嗜中性粒细胞抗原CD177抗体 ,规格: 0.1ml ,英文名: Anti-CD177/NB1(Neutrophil Glycoprotein NB1)
Ab-(010)-13733 CD167a抗体 ,规格: 0.1ml ,英文名: Anti-CD167a/DDR1
Ab-(010)-13734 NK细胞抑制性受体3DL1抗体 ,规格: 0.1ml ,英文名: Anti-CD158e/KIR3DL1(Killer cell immunoglobulin-like receptor 3DL1)
Ab-(010)-13735 NK细胞抑制性受体2DL1抗体 ,规格: 0.1ml ,英文名: Anti-CD158a/KIR2DL1(Killer cell immunoglobulin-like receptor 2DL1)
Ab-(010)-13736 细胞外基质金属蛋白酶诱导因子抗体 ,规格: 0.1ml ,英文名: Anti-CD147/EMMPRIN(Extracellular matrix metalloproteinase inducer)
Ab-(010)-13737 CD14/内毒素受体抗体 ,规格: 0.1ml ,英文名: Anti-CD14(cluster of differentiation antigen 14)
Ab-(010)-13738 氨肽酶N抗体 ,规格: 0.1ml ,英文名: Anti-CD13/ANPEN(Aminopeptidase N)
Ab-(010)-13739 凝血调节蛋白抗体 ,规格: 0.1ml ,英文名: Anti-CD141(Thrombomodulin)
Ab-(010)-13740 黑色素瘤细胞粘附分子CD146抗体 ,规格: 0.1ml ,英文名: Anti-CD146/MCAM
Ab-(010)-13741 多配体蛋白聚糖1抗体 ,规格: 0.1ml ,英文名: Anti-CD138/Syndecan-1
Ab-(010)-13742 造血干细胞抗原CD133抗体 ,规格: 0.1ml ,英文名: Anti-CD133 antigen
Ab-(010)-13743 抗磷酸化原癌基因c-kit抗体 ,规格: 0.1ml ,英文名: Anti-phospho-c-kit/SCFR/CD117(pTyr936)
Ab-(010)-13744 CD105/转化生长因子β受体抗体 ,规格: 0.1ml ,英文名: Anti-CD105/Endoglin/TGF-β receptor
Ab-(010)-13745 细胞周期相关激酶抗体 ,规格: 0.1ml ,英文名: Anti-CCRK(Cell cycle related kinase)
Ab-(010)-13746 细胞表面趋化因子受体10抗体 ,规格: 0.1ml ,英文名: Anti-CCR-10(C-C chemokine receptor 10)
Ab-(010)-13747 粘膜相关上皮趋化因子MEC抗体 ,规格: 0.1ml ,英文名: Anti-CCL28(CC Chemokine Ligand 28)
Ab-(010)-13748 细胞表面趋化因子受体9抗体 ,规格: 0.1ml ,英文名: Anti-CCR-9(C-C chemokine receptor 9)
Ab-(010)-13749 细胞表面趋化因子受体8抗体 ,规格: 0.1ml ,英文名: Anti-CCR-8(C-C chemokine receptor 8)
Ab-(010)-13750 CXCL10趋化因子10/干扰素诱导蛋白10抗体 ,规格: 0.1ml ,英文名: anti-CXCL10/IP-10
Ab-(010)-13751 细胞表面趋化因子受体7抗体 ,规格: 0.1ml ,英文名: Anti-CCR-7(C-C chemokine receptor 7)
Ab-(010)-13752 细胞表面趋化因子受体6抗体 ,规格: 0.1ml ,英文名: Anti-CCR-6/CD196(C-C chemokine receptor type 6)
Ab-(010)-13753 细胞表面趋化因子受体2B抗体 ,规格: 0.1ml ,英文名: Anti-CCR-2B(C-C Chemokine receptor 2B)
Ab-(010)-13754 细胞表面趋化因子受体2A抗体 ,规格: 0.1ml ,英文名: Anti-CCR-2A(C-C Chemokine receptor 2A)
Ab-(010)-13755 细胞表面趋化因子受体2/5抗体 ,规格: 0.1ml ,英文名: Anti-CCR-2/5(CC chemokine receptor 2/5)
Ab-(010)-13756 嗜酸粒细胞趋化蛋白3抗体 ,规格: 0.1ml ,英文名: Anti-CCL26(Eotaxin 3)
Ab-(010)-13757 嗜酸粒细胞趋化蛋白22抗体 ,规格: 0.1ml ,英文名: Anti-CCL22/MDC(small inducible cytokine A22 precursor)
Ab-(010)-13758 淋巴细胞趋化因子CCL21抗体 ,规格: 0.1ml ,英文名: Anti-CCL21/6Ckine(Chemokine (C-C motif) ligand 21)
Ab-(010)-13759 巨噬细胞来源的趋化因子抗体 ,规格: 0.1ml ,英文名: Anti-CCL22/MDC(CC chemokine ABCD-1)
Ab-(010)-13760 嗜酸粒细胞趋化蛋白抗体 ,规格: 0.1ml ,英文名: Anti-CCL11(Eotaxin 1)
Ab-(010)-13761 巨噬细胞炎性蛋白3α抗体 ,规格: 0.1ml ,英文名: Anti-CCL20/MIP3αMacrophage inflammatory ptotein 3 alpha)
Ab-(010)-13762 调节活化的正常T细胞表达和分泌的因子(趋化因子) ,规格: 0.1ml ,英文名: Anti-CCL5/RANTES(regulated on activation normal T cell expressed and secreted)
Ab-(010)-13763 瓜氨酸环肽抗体 ,规格: 0.1ml ,英文名: Anti-CCP (cyclic citrullinated peptide)
Ab-(010)-13764 克拉拉细胞蛋白(Clara细胞分泌蛋白)抗体 ,规格: 0.1ml ,英文名: Anti-CC16(Clara cell protein 16)
Ab-(010)-13765 胆囊收缩素抗体/缩胆囊素抗体(八肽) ,规格: 0.1ml ,英文名: Anti-CCK8(Cholecystokinin-8)
Ab-(010)-13766 CBX5抗体 ,规格: 0.1ml ,英文名: Anti-CBX5(Chromobox Homolog 5)
Ab-(010)-13767 染色盒同源物3抗体 ,规格: 0.1ml ,英文名: Anti-CBX3(Chromobox homolog 3)
Ab-(010)-13768 CREB结合蛋白抗体 ,规格: 0.1ml ,泛素蛋白连接酶E2抗体英文名: Anti-CBP(CREB-binding protein)
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