供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-5090 |
CAS号: | 详见产品说明书 |
心脏和神经嵴衍生蛋白1抗体
〖别名〗autonomic nervous system and neural crest derivatives-expressed protein 1; heart; Basic helix loop helix transcription factor HAND1; Class A basic helix-loop-helix protein 27; Extraembryonic tissues; Extraembryonic tissues heart autonomic nervous system and neural crest derivatives expressed protein 1; HAND 1; HAND1; HAND-1; HAND1_HUMAN; Heart and neural crest derivatives expressed 1; Heart and neural crest derivatives expressed protein 1; Heart-and neural crest derivatives-expressed protein 1; Hxt; Thing 1; Thing1.
〖浓度〗1mg/1ml
〖规格〗0.2ml/200μg
〖抗体来源〗Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗心脏和神经嵴衍生蛋白1抗体Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Dog
〖产品类型〗一抗
〖研究领域〗心血管 发育生物学 干细胞 转录调节因子 表观遗传学
〖蛋白分子量〗predicted molecular weight: 24kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated synthetic peptide derived from human HAND1
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
〖产品应用〗ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes.dHAND (for deciduum, heart, autonomic nervous system and neural crest derivatives; also designated HAND2) and eHAND (also designated HAND1, HXT or Thing1) are members of a subclass of basic-helix-loop-helix transcription factors that are involved in cardiac development. dHAND and eHAND are expressed in the heart after cardiac looping, and they participate in left-right cardiac asymmetry. dHAND is expressed predominantly on the right side of the looped heart tube and in the pulmonary ventricle, where it activates transcription of various genes, including Ufd1 (for ubiquitin fusion degradation) and Cdc45. In addition, dHAND is expressed in sympathetic neurons and chromafin cells throughout embryonic and fetal development and mediates neural crest development. eHAND expression is primarily observed on the left side and in the systemic ventricle, suggesting that these proteins are involved in the development of segments of the heart tube, which give rise to specific heart chambers during cardiogenesis.
Function : Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity).
Subunit : Efficient DNA binding requires dimerization with another bHLH protein. Forms homodimers and heterodimers with TCF3 gene products E12 and E47, HAND2 and HEY1, HEY2 and HEYL (hairy-related transcription factors). Interacts with MDFIC (By similarity).
Subcellular Location : Nucleus.
Tissue Specificity : Heart.
Post-translational modifications : Phosphorylation by PLK4 disrupts the interaction with MDFIC and leads to tranlocation into the nucleoplasm, allowing dimerization and transcription factor activity (By similarity).
Similarity : Contains 1 bHLH (basic helix-loop-helix) domain.
Database links : UniProtKB/Swiss-Prot: O96004.1
做过实验的亲们都知道心脏和神经嵴衍生蛋白1抗体反应规律,仔细观察我们会发现当抗原第一次进入机体时,需经一定的潜伏期才能产生抗体,且抗体产生的量也不多,在体内维持的时间也较短。当相同抗原第二次进入机体后,开始时,由于原有抗体中的一部分与再次进入的抗原结合,可使原有抗体量略为降低。随后,抗体效价迅速大量增加,可比初次反应产生的多几倍到几十倍,在体内留存的时间亦较长。因此得出由抗原刺激机体产生的抗体,经过一定时间后可逐渐消失。此时若再次接触抗原,可使已消失的抗体快速上升。如再次刺激机体的抗原与初次相同,则称为特异性回忆反应;若与初次反应不同,则称为非特异性回忆反应。
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Ab-(010)-16126 Anti-CNGA2/FITC 荧光素标记抗环核苷酸阳离子通道蛋白α2抗体IgG ,规格: 0.2ml ,英文名: Anti-CNGA2/FITC
Ab-(010)-16127 Anti-c-Myc tag/HRP 辣根过氧化物酶标记c-Myc tag标签抗体IgG ,规格: 0.2ml ,英文名: Anti-c-Myc
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Ab-(010)-16129 Anti-C-Myc/MYC/MTLC /FITC 荧光素标记C-Myc致癌基因抗体IgG ,规格: 0.2ml ,英文名: Anti-C-Myc/MYC/MTLC
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Ab-(010)-16131 Anti-SM-MHC/FITC 荧光素标记心肌肌凝蛋白抗体IgG ,规格: 0.2ml ,英文名: Anti-SM-MHC/FITC
Ab-(010)-16132 Anti-SMMHC/MYH11/FITC 荧光素标记平滑肌肌球蛋白重链抗体IgG ,规格: 0.2ml ,英文名: Anti-SMMHC/MYH11/FITC
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Ab-(010)-16134 Anti-C-Met/HGFR /FITC 荧光素标记肝细胞生长因子受体(原癌基因蛋白)抗体IgG ,规格: 0.2ml ,英文名: Anti-C-Met/HGFR
Ab-(010)-16135 Anti-C-Mer/MERTK /FITC 荧光素标记c-mer原癌基因酪氨酸激酶抗体IgG ,规格: 0.2ml ,英文名: Anti-C-Mer/MERTK
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Ab-(010)-16140 Anti-Cortactin (phospho Tyr466) /FITC 荧光素标记兔抗人、大、小鼠磷酸化皮层肌动蛋白抗体IgG ,规格: 0.2ml ,英文名: Anti-Cortactin
Ab-(010)-16141 Anti-Cortactin/FITC 荧光素标记兔抗人、大、小鼠皮层肌动蛋白抗体IgG ,规格: 0.2ml ,英文名: Anti-Cortactin/FITC
Ab-(010)-16142 Anti-Phospho-Cofilin (Ser3) /FITC 荧光素标记兔抗人、大、小鼠磷酸化丝切蛋白抗体IgG ,规格: 0.2ml ,英文名: Anti-Phospho-Cofilin
Ab-(010)-16143 Anti-cofilin/FITC 荧光素标记兔抗人、大、小鼠丝切蛋白抗体IgG ,规格: 0.2ml ,英文名: Anti-cofilin/FITC
Ab-(010)-16144 Anti-Clostridium perfringens type D/FITC 荧光素标记兔抗D型产气荚膜梭菌抗体IgG ,规格: 0.2ml ,英文名: Anti-Clostridium
Ab-(010)-16145 Anti-CLEC13D/MMR1/CD206/FITC 荧光素标记巨噬细胞甘露糖受体抗体IgG ,规格: 0.2ml ,英文名: Anti-CLEC13D/MMR1/CD206/FITC
Ab-(010)-16146 Anti-CLEC5A/MDL1/FITC 荧光素标记C型凝集素结构域家族5成员A抗体IgG ,规格: 0.2ml ,英文名: Anti-CLEC5A/MDL1/FITC
Ab-(010)-16147 Anti-CLEC2D/OCIL/FITC 荧光素标记CLEC2D蛋白抗体IgG ,规格: 0.2ml ,英文名: Anti-CLEC2D/OCIL/FITC
Ab-(010)-16148 Anti-CLEC-2/CLEC1B/FITC 荧光素标记C型凝集素结构域家族1成员B抗体IgG ,规格: 0.2ml ,英文名: Anti-CLEC-2/CLEC1B/FITC
Ab-(010)-16149 Anti-CLEC-1/CLEC1A/FITC 荧光素标记C型凝集素结构域家族1成员A抗体IgG ,规格: 0.2ml ,英文名: Anti-CLEC-1/CLEC1A/FITC
Ab-(010)-16150 Anti-CLDN5/FITC 荧光素标记紧密连接蛋白5抗体IgG ,规格: 0.2ml ,英文名: Anti-CLDN5/FITC
Ab-(010)-16151 Anti-CLDN4/Claudin 4/FITC 荧光素标记紧密连接蛋白4抗体IgG ,规格: 0.2ml ,英文名: Anti-CLDN4/Claudin
Ab-(010)-16152 Anti-CLDN3/Claudin 3/FITC 荧光素标记紧密连接蛋白3抗体IgG ,规格: 0.2ml ,英文名: Anti-CLDN3/Claudin
Ab-(010)-16153 Anti-ocludin-5/FITC 荧光素标记紧密连接蛋白-5抗体IgG ,规格: 0.2ml ,英文名: Anti-ocludin-5/FITC
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Ab-(010)-16161 Anti-CK34 BetaE12/FITC 荧光素标记高分子量角蛋白CK34βE12抗体IgG ,规格: 0.2ml ,英文名: Anti-CK34
Ab-(010)-16162 Anti-CK20/FITC 荧光素标记细胞角蛋白20抗体IgG ,规格: 0.2ml ,英文名: Anti-CK20/FITC
Ab-(010)-16163 Anti-CK19/RBITC 红色荧光素罗丹明标记细胞角蛋白19抗体IgG ,规格: 0.2ml ,英文名: Anti-CK19/RBITC
Ab-(010)-16164 Anti-CK19/FITC 荧光素标记细胞角蛋白19抗体IgG ,规格: 0.2ml ,英文名: Anti-CK19/FITC
Ab-(010)-16165 Anti-CK19/Gold 胶体金离子标记细胞角蛋白19抗体IgG ,规格: 0.2ml ,心脏和神经嵴衍生蛋白1抗体英文名: Anti-CK19/Gold
Ab-(010)-16166 Anti-CK19/FITC 荧光素标记细胞角蛋白19抗体IgG ,规格: 0.2ml ,英文名: Anti-CK19/FITC
Ab-(010)-16167 Anti-CK18/FITC 荧光素标记细胞角蛋白18抗体IgG ,规格: 0.2ml ,英文名: Anti-CK18/FITC
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