供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-5091 |
CAS号: | 详见产品说明书 |
雌激素下调基因1蛋白抗体
〖别名〗Cardiac lineage protein 1; CLP 1; CLP1; EDG 1; EDG1; Estrogen down-regulated gene 1 protein; Hexamethylene bis acetamide inducible 1; Hexamethylene bis acetamide inducible protein; Hexamethylene bis acetamide inducible transcript 1; Hexamethylene bis-acetamide-inducible protein 1; HEXI1_HUMAN; HEXIM 1; Hexim1; HEXIM1 protein; HIS 1; HIS1; HMBA inducible; MAQ 1; MAQ1; Menage a quatre 1; Menage a quatre protein 1; Protein HEXIM1.
〖浓度〗1mg/1ml
〖规格〗0.2ml/200μg
〖抗体来源〗Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗雌激素下调基因1蛋白抗体Human, Mouse, Rat, Horse
〖产品类型〗一抗
〖研究领域〗心血管 细胞生物 转录调节因子 表观遗传学
〖蛋白分子量〗predicted molecular weight: 41kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated synthetic peptide derived from human HEXIM1/EDG1
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
〖产品应用〗WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗Hexamethylene bis-acetamide inducible 1 (HEXIM1) and Hexamethylene bis-acetamide inducible 2 (HEXIM2) comprise a family of proteins which inhibit positive transcription elongation factor b (P-TEFb) through association with 7SK. P-TEFb is composed of a catalytic subunit, Cdk9, and either Cyclin T1 or T2 as a regulatory subunit. This complex regulates eukaryotic gene expression at the level of elongation. The C-terminal domains of HEXIM proteins interact directly with each other. Via these domains, HEXIM1 and HEXIM2 form stable homo- and hetero-oligomers, which may aid in the formation of the 7SK small nuclear ribonucleic acid particle. Despite their similar functions, HEXIM1 and HEXIM2 exhibit distinct expression patterns in various established cell lines and human tissues.
Function : Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
Subunit : Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1. Interacts with ESR1 and NR3C1. May interact with NF-kappa-B through RELA.
Subcellular Location : Nucleus. Cytoplasm. Binds alpha-importin and is mostly nuclear.
Tissue Specificity : Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.
Similarity : Belongs to the HEXIM family.
Database links : UniProtKB/Swiss-Prot: O94992.1
做过实验的亲们都知道雌激素下调基因1蛋白抗体反应规律,仔细观察我们会发现当抗原第一次进入机体时,需经一定的潜伏期才能产生抗体,且抗体产生的量也不多,在体内维持的时间也较短。当相同抗原第二次进入机体后,开始时,由于原有抗体中的一部分与再次进入的抗原结合,可使原有抗体量略为降低。随后,抗体效价迅速大量增加,可比初次反应产生的多几倍到几十倍,在体内留存的时间亦较长。因此得出由抗原刺激机体产生的抗体,经过一定时间后可逐渐消失。此时若再次接触抗原,可使已消失的抗体快速上升。如再次刺激机体的抗原与初次相同,则称为特异性回忆反应;若与初次反应不同,则称为非特异性回忆反应。
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Ab-(010)-16169 Anti-CK18/FITC 荧光素标记细胞角蛋白18抗体IgG ,规格: 0.2ml ,英文名: Anti-CK18/FITC
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Ab-(010)-16171 Anti-CK17/FITC 荧光素标记细胞角蛋白17抗体IgG ,规格: 0.2ml ,英文名: Anti-CK17/FITC
Ab-(010)-16172 Anti-CK16/FITC 荧光素标记细胞角蛋白16抗体IgG ,规格: 0.2ml ,英文名: Anti-CK16/FITC
Ab-(010)-16173 Anti-CK15/FITC 荧光素标记细胞角蛋白15抗体IgG ,规格: 0.2ml ,英文名: Anti-CK15/FITC
Ab-(010)-16174 Anti-CK14/FITC 荧光素标记兔抗细胞角蛋白14抗体IgG ,规格: 0.2ml ,英文名: Anti-CK14/FITC
Ab-(010)-16175 Anti-CK10/RBITC 红色荧光素罗丹明标记细胞角蛋白10抗体IgG ,规格: 0.2ml ,英文名: Anti-CK10/RBITC
Ab-(010)-16176 Anti-CK10/FITC 荧光素标记细胞角蛋白10抗体IgG ,规格: 0.2ml ,英文名: Anti-CK10/FITC
Ab-(010)-16177 Anti-CK7/FITC 荧光素标记抗细胞角蛋白7抗体(大、小鼠)IgG ,规格: 0.2ml ,英文名: Anti-CK7/FITC
Ab-(010)-16178 Anti-CK7/FITC 荧光素标记细胞角蛋白7抗体IgG ,规格: 0.2ml ,英文名: Anti-CK7/FITC
Ab-(010)-16179 Anti-CK5/6 /FITC 荧光素标记细胞角蛋白5/6抗体IgG ,规格: 0.2ml ,英文名: Anti-CK5/6
Ab-(010)-16180 Anti-PCNA(phosphos Dyr211)/FITC 荧光素标记兔抗人、小鼠、大鼠、牛、兔、羊、鸡磷酸化增殖细胞核抗原抗体IgG ,规格: 0.2ml ,英文名: Anti-PCNA
Ab-(010)-16181 Anti-CK5/FITC 荧光素标记细胞角蛋白5抗体IgG ,规格: 0.2ml ,英文名: Anti-CK5/FITC
Ab-(010)-16182 Anti-CK4/FITC 荧光素标记细胞角蛋白4抗体IgG ,规格: 0.2ml ,英文名: Anti-CK4/FITC
Ab-(010)-16183 Anti-CK3/FITC 荧光素标记细胞角蛋白3抗体IgG ,规格: 0.2ml ,英文名: Anti-CK3/FITC
Ab-(010)-16184 Anti-CK2/FITC 荧光素标记酪氨酸激酶2抗体IgG ,规格: 0.2ml ,英文名: Anti-CK2/FITC
Ab-(010)-16185 Anti-phospho-c-Jun (Ser73) /FITC 荧光素标记兔抗人、大、小鼠磷酸化原癌基因c-Jun抗体IgG ,规格: 0.2ml ,英文名: Anti-phospho-c-Jun
Ab-(010)-16186 Anti-C-jun/AP-1 /FITC 荧光素标记原癌基因蛋白/活化蛋白1抗体IgG ,规格: 0.2ml ,英文名: Anti-C-jun/AP-1
Ab-(010)-16187 Anti-CIDEB/FITC 荧光素标记CIDEB抗体IgG ,规格: 0.2ml ,英文名: Anti-CIDEB/FITC
Ab-(010)-16188 Anti-CIDE-B/FITC 荧光素标记促进凋亡基因抗体IgG ,规格: 0.2ml ,英文名: Anti-CIDE-B/FITC
Ab-(010)-16189 anti-CIB1/FITC 荧光素标记钙-整合素结合蛋白1抗体IgG ,规格: 0.2ml ,英文名: anti-CIB1/FITC
Ab-(010)-16190 Anti-ChRM3/FITC 荧光素标记毒蕈碱型乙酰胆碱受体M3抗体IgG ,规格: 0.2ml ,英文名: Anti-ChRM3/FITC
Ab-(010)-16191 Anti-ChRM2/FITC 荧光素标记毒蕈碱型乙酰胆碱受体M2抗体 IgG ,规格: 0.2ml ,英文名: Anti-ChRM2/FITC
Ab-(010)-16192 Anti-ChRM2/FITC 荧光素标记毒蕈碱型乙酰胆碱受体M2抗体IgG ,规格: 0.2ml ,英文名: Anti-ChRM2/FITC
Ab-(010)-16193 Anti-ChRM1 /FITC 荧光素标记毒蕈碱型乙酰胆碱受体M1抗体IgG ,规格: 0.2ml ,英文名: Anti-ChRM1
Ab-(010)-16194 Anti-Chloramphenicol/FITC 荧光素标记抗氯霉素抗体IgG ,规格: 0.2ml ,英文名: Anti-Chloramphenicol/FITC
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Ab-(010)-16196 Anti-CHK2/Cds1 /FITC 荧光素标记抗细胞周期检测点激酶2抗体IgG ,规格: 0.2ml ,英文名: Anti-CHK2/Cds1
Ab-(010)-16197 Anti-CHK1/FITC 荧光素标记抗细胞周期检测点激酶1抗体IgG ,规格: 0.2ml ,英文名: Anti-CHK1/FITC
Ab-(010)-16198 Anti-ChAT/FITC 荧光素标记ChAT抗体IgG ,规格: 0.2ml ,英文名: Anti-ChAT/FITC
Ab-(010)-16199 Anti-CGRP/FITC 荧光素标记降钙素基因相关肽抗体IgG ,规格: 0.2ml ,英文名: Anti-CGRP/FITC
Ab-(010)-16200 Anti-CGP-39/YKL-40/FITC 荧光素标记软骨糖蛋白39抗体IgG ,规格: 0.2ml ,英文名: Anti-CGP-39/YKL-40/FITC
Ab-(010)-16201 Anti-CGB/FITC 荧光素标记嗜铬粒素B抗体IgG ,规格: 0.2ml ,英文名: Anti-CGB/FITC
Ab-(010)-16202 Anti-CG6856/CG6856-PA/FITC 荧光素标记兔抗果蝇CG6856-PA抗体IgG ,规格: 0.2ml ,英文名: Anti-CG6856/CG6856-PA/FITC
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Ab-(010)-16210 Anti-C-erbB-4/HER4/erbB-4 /FITC 荧光素标记c-erbB-4癌基因抗体IgG ,规格: 0.2ml ,英文名: Anti-C-erbB-4/HER4/erbB-4
Ab-(010)-16211 Anti-Phospho-HER4 (Tyr1284) /FITC 荧光素标记磷酸化HER4抗体IgG ,规格: 0.2ml ,英文名: Anti-Phospho-HER4
Ab-(010)-16212 Anti-Phospho-HER3 (Tyr1222) /FITC 荧光素标记磷酸化HER3受体抗体IgG ,规格: 0.2ml ,英文名: Anti-Phospho-HER3
Ab-(010)-16213 Anti-Phospho-HER3(Tyr1197) /FITC 荧光素标记磷酸化HER3受体抗体IgG ,规格: 0.2ml ,雌激素下调基因1蛋白抗体英文名: Anti-Phospho-HER3
Ab-(010)-16214 Anti-Phospho-CENP-A (Ser7)/FITC 荧光素标记兔抗人、大、小鼠磷酸化着丝粒蛋白A抗体IgG ,规格: 0.2ml ,英文名: Anti-Phospho-CENP-A
Ab-(010)-16215 Anti-CENPA /FITC 荧光素标记兔抗人、大、小鼠着丝粒蛋白A抗体IgG ,规格: 0.2ml ,英文名: Anti-CENPA
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