供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-5110 |
CAS号: | 详见产品说明书 |
Fas相互作用蛋白激酶2抗体
〖别名〗hHIPk 2; hHIPk2; HIPK 2; Hipk2; HIPK2_HUMAN; Homeodomain interacting protein kinase 2; Homeodomain-interacting protein kinase 2; Nbak1; Nuclear body-associated kinase 1; PRO0593; Sialophorin tail-associated nuclear serine/threonine-protein kinase; Stank.
〖浓度〗1mg/1ml
〖规格〗0.2ml/200μg
〖抗体来源〗Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗Fas相互作用蛋白激酶2抗体Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit
〖产品类型〗一抗
〖研究领域〗肿瘤 细胞生物 免疫学 信号转导 转录调节因子 激酶和磷酸酶 表观遗传学
〖蛋白分子量〗predicted molecular weight: 131kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated synthetic peptide derived from human HIPK2
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
〖产品应用〗WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗Protein kinase acting as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Inhibits cell growth and promotes apoptosis. Involved in transcriptional activation of TP53 and TP73. Phosphorylation of TP53 may be mediated by a TP53-HIPK2-AXIN1 complex. In response to TGFB, cooperates with DAXX to activate JNK. Phosphorylates the antiapoptotic factor CTBP1 and promotes its proteasomal degradation. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between TAK1 and NLK to promote the proteasomal degradation of MYB (By similarity). Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
Subunit : Interacts with CREB1, SIAH1, WSB1, CBX4, TRADD, p53/TP53, TP73, TP63, CREBBP, DAXX, P53DINP1, SKI, SMAD1, SMAD2 and SMAD3, but not SMAD4. Interacts with ATF1, PML, RUNX1, EP300, NKX1-2, NKX2-5, SPN/CD43, UBE2I, HMGA1, CTBP1, AXIN1, NLK, MYB, POU4F1, POU4F2, POU4F3, UBE2I, UBL1 and ZBTB4. Probably part of a complex consisting of p53/TP53, HIPK2 and AXIN1.
Subcellular Location : Nucleus, PML body. Cytoplasm.
Tissue Specificity : Highly expressed in heart, muscle and kidney. Weakly expressed in a ubiquitous way. Down-regulated in several thyroid and breast tumors.
Similarity : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. Contains 1 protein kinase domain.
Database links : UniProtKB/Swiss-Prot: Q9H2X6.2
做过实验的亲们都知道Fas相互作用蛋白激酶2抗体反应规律,仔细观察我们会发现当抗原第一次进入机体时,需经一定的潜伏期才能产生抗体,且抗体产生的量也不多,在体内维持的时间也较短。当相同抗原第二次进入机体后,开始时,由于原有抗体中的一部分与再次进入的抗原结合,可使原有抗体量略为降低。随后,抗体效价迅速大量增加,可比初次反应产生的多几倍到几十倍,在体内留存的时间亦较长。因此得出由抗原刺激机体产生的抗体,经过一定时间后可逐渐消失。此时若再次接触抗原,可使已消失的抗体快速上升。如再次刺激机体的抗原与初次相同,则称为特异性回忆反应;若与初次反应不同,则称为非特异性回忆反应。
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Ab-(010)-17106 VCAM-1/CD106 (Vascuolar cell adhesion molecule 1) 血管内皮细胞粘附分子抗原 ,规格: 0.5mg ,英文名: VCAM-1/CD106
Ab-(010)-17107 VCAM-1/CD106(Vascular cell adhesion molecule 1 isoform b precusor; CD106 antigen) 血管内皮细胞粘附分子抗原 ,规格: 0.5mg ,英文名: VCAM-1/CD106
Ab-(010)-17108 VASH1(Vasohibin 1) 兔抗血管抑制蛋白1抗原 ,规格: 0.5mg ,英文名: VASH1
Ab-(010)-17109 Ubiquitin 泛素蛋白抗原 ,规格: 0.5mg ,英文名: Ubiquitin
Ab-(010)-17110 USF-1(upstream stimulatory factor 1) 上游刺激因子1抗原 ,规格: 0.5mg ,英文名: USF-1
Ab-(010)-17111 UCN(Urocortin)mouse ret 新型血管活性因子UCN抗原(小鼠、大鼠) ,规格: 0.5mg ,英文名: UCN
Ab-(010)-17112 T Beta10 peptide 胸腺素β10抗原 ,规格: 0.5ml ,英文名: T
Ab-(010)-17113 TWIST protein peptide TWIST蛋白抗原 ,规格: 0.5mg ,英文名: TWIST
Ab-(010)-17114 Tubulin- Gamma 微管蛋白-γ抗原 ,规格: 0.5mg ,英文名: Tubulin-
Ab-(010)-17115 TTF-1 (Thyroid Transcription Factor-1) 甲状腺核转录因子-1抗原 ,规格: 0.5mg ,英文名: TTF-1
Ab-(010)-17116 TSLC1 (tumor suppressor in lung cancer-1) 肺癌肿瘤阻抑基因1抗原 ,规格: 0.5mg ,英文名: TSLC1
Ab-(010)-17117 MAP1LC3A(microtubule-associated protein 1 light chain 3) 自噬微管相关蛋白轻链3抗原 ,规格: 0.5mg ,英文名: MAP1LC3A
Ab-(010)-17118 TSHR (Thyroid stimulating hormone receptor) 促甲状腺素受体抗原 ,规格: 0.5mg ,英文名: TSHR
Ab-(010)-17119 Tsg101(Tumor susceptibility gene 101 protein) Tsg101抗原 ,规格: 0.5mg ,英文名: Tsg101
Ab-(010)-17120 CIDEB peptide CIDEB抗原 ,规格: 0.5mg ,英文名: CIDEB
Ab-(010)-17121 TSGF(Tumor Specific Growth Fanctor) 恶性肿瘤特异性生长因子抗原 ,规格: 0.5mg ,英文名: TSGF
Ab-(010)-17122 TSARG4(Testis and spermatogenesis related gene 4) 生精细胞凋亡相关基因4抗原 ,规格: 0.5mg ,英文名: TSARG4
Ab-(010)-17123 Trop-2/Tpm2 peptide 原肌球蛋白抗原 ,规格: 0.5mg ,英文名: Trop-2/Tpm2
Ab-(010)-17124 TRIM32(tripartite motif protein 32) TRIM32抗原 ,规格: 0.5mg ,英文名: TRIM32
Ab-(010)-17125 TRBF1 (Telomeric repeat binding factor 1) 端粒体复制结合因子1抗原 ,规格: 0.5mg ,英文名: TRBF1
Ab-(010)-17126 TRAIL/Apo2L (tumor necrosis factor-related apoptosis-inducing ligand) 肿瘤坏死因子相关凋亡诱导配体/凋亡素2配体抗原 ,规格: 0.5mg ,英文名: TRAIL/Apo2L
Ab-(010)-17127 TRAF6 (TNF receptor-associated factor 6) 肿瘤坏死因子受体相关因子6抗原 ,规格: 0.5mg ,英文名: TRAF6
Ab-(010)-17128 TRAF3/CD40bp (CD40 binding protein) 肿瘤坏死因子受体相关蛋白3抗原 ,规格: 0.5mg ,英文名: TRAF3/CD40bp
Ab-(010)-17129 TRAF2/TNF-R2 (TNF receptor-associated factor 2) 肿瘤坏死因子受体相关因子2抗原 ,规格: 0.5ml ,英文名: TRAF2/TNF-R2
Ab-(010)-17130 TRAF1 肿瘤坏死因子受体相关因子1抗原 ,规格: 0.5mg ,英文名: TRAF1
Ab-(010)-17131 TRADD(TNF receptor 1 associated via death domain) 有死亡区的肿瘤坏死因子受体1相关蛋白抗原 ,规格: 0.5mg ,英文名: TRADD
Ab-(010)-17132 TRA16 (Testicular orphan nuclear receptor-4 (TR4)-associated protein) 睾丸激素受体相关蛋白/孤儿素受体相关蛋白(抗原) ,规格: 0.5mg ,英文名: TRA16
Ab-(010)-17133 TPH (Trptophan Hydroxylase) 色氨酸羟化酶(多肽) ,规格: 0.5mg ,英文名: TPH
Ab-(010)-17134 TOPO II Alpha/DNA TP II Alpha (DNA topoisomerase II Alpha) DNA拓普西异构酶Ⅱ抗原 ,规格: 0.5mg ,英文名: TOPO
Ab-(010)-17135 TP I (topoisomerase I ) 拓普西异构酶Ⅰ抗原 ,规格: 0.5mg ,英文名: TP
Ab-(010)-17136 TP53(tumor protein p53; Li-Fraumeni syndrome) 抗肿瘤P53抗原 ,规格: 0.5ml ,英文名: TP53
Ab-(010)-17137 TNFAIP1(Tumor necrosis factor-alpha-induced protein 1) 肿瘤坏死因子α诱导蛋白1抗原 ,规格: 0.5mg ,英文名: TNFAIP1
Ab-(010)-17138 TNF- Beta(Tumor Necrosis Factor- Beta) 肿瘤坏死因子-β抗原 ,规格: 0.5mg ,英文名: TNF-
Ab-(010)-17139 TNF-alpha 肿瘤坏死因子-α抗原 ,规格: 0.5mg ,英文名: TNF-alpha
Ab-(010)-17140 Tn-C(Tenascin-C)C-Terminus 腱糖蛋白-C(固生蛋白)C端抗原 ,规格: 0.5mg ,英文名: Tn-C
Ab-(010)-17141 TM(Thrombomodulin) 血栓调节蛋白多肽 ,规格: 0.5mg ,英文名: TM
Ab-(010)-17142 TLR5/CD285 (Toll-like receptor 5) Toll样受体5抗原 ,规格: 0.5mg ,英文名: TLR5/CD285
Ab-(010)-17143 TLR4/CD284 (Toll-like receptor 4) Toll样受体4抗原 ,规格: 0.5mg ,英文名: TLR4/CD284
Ab-(010)-17144 TLR3 (Toll-like receptor 3) Toll样受体3抗原 ,规格: 0.5mg ,英文名: TLR3
Ab-(010)-17145 Rarres2/TIG2/Chemerin(Retinoic acid receptor responder protein 2) 视黄酸受体应答蛋白2抗原 ,规格: 0.5mg ,英文名: Rarres2/TIG2/Chemerin
Ab-(010)-17146 Tie2(Porcine tyrosine kinase with immunoglobulin-like and EGF-like domains 2) 上皮生长因子样域酪氨酸激酶2抗原 ,规格: 0.5mg ,英文名: Tie2
Ab-(010)-17147 Tie1/JTK14 peptide 上皮生长因子样域酪氨酸激酶1抗原 ,规格: 0.5mg ,英文名: Tie1/JTK14
Ab-(010)-17148 Thioredoxin 1(ERdj5) 硫氧还蛋白抗原 ,规格: 0.5mg ,英文名: Thioredoxin
Ab-(010)-17149 TGF- BetaR1/ALK (TGF-beta receptor type I) 转移生长因子–β受体1抗原 ,规格: 0.5mg ,英文名: TGF-
Ab-(010)-17150 TIEG1/KLF10(TGF-beta inducible early response gene 1) TGF-β诱导早期应答基因1抗原 ,规格: 0.5mg ,英文名: TIEG1/KLF10
Ab-(010)-17151 TFPI-2 (tissue factor pathway inhibitor-2) 组织因子途径抑制剂-2抗原 ,规格: 0.5mg ,英文名: TFPI-2
Ab-(010)-17152 TFF3 (trefoil factor3) 三叶肽因子3(多肽) ,规格: 0.5mg ,英文名: TFF3
Ab-(010)-17153 TEM 1/CD248(Tumor endothelial marker 1 precursor) 内涎蛋白/内皮唾液酸蛋白抗原 ,规格: 0.5mg ,英文名: TEM
Ab-(010)-17154 Tenascin 固生蛋白抗原 ,规格: 0.5mg ,英文名: Tenascin
Ab-(010)-17155 TDP-43/TARDBP (tar DNA binding protein) Tar DNA 结合蛋白43抗原 ,规格: 0.5mg ,英文名: TDP-43/TARDBP
Ab-(010)-17156 TCF7L2(transcription factor 7-like 2) 转录因子7类似物2抗原 ,规格: 0.5mg ,英文名: TCF7L2
Ab-(010)-17157 TBX2/T-box2(T-box Protein 2) 新型抑癌基因(多肽) ,规格: 0.5mg ,英文名: TBX2/T-box2
Ab-(010)-17158 MAP1A/Mtap1a(microtubule associated protein 1A) 微管相关蛋白1A抗原 ,规格: 0.5mg ,Fas相互作用蛋白激酶2抗体英文名: MAP1A/Mtap1a
Ab-(010)-17159 MAP-2(microtubule associated protein 2) 微管相关蛋白2抗原 ,规格: 0.5mg ,英文名: MAP-2
Ab-(010)-17160 phospho-Tau protein (pThr489) peptide 磷酸化微管相关蛋白 ,规格: 0.5mg ,英文名: phospho-Tau
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