供货周期: | 一周 |
品牌: | EterLife |
规格: | 0.1ml/100μg 、0.2ml/200μg |
货号: | TE-KT-5111 |
CAS号: | 详见产品说明书 |
Fas相互作用蛋白激酶3抗体
〖别名〗FIST3; Androgen receptor interacting nuclear protein kinase; Androgen receptor-interacting nuclear protein kinase; ANPK; DYRK6; Fas interacting serine/threonine protein kinase; Fas-interacting serine/threonine-protein kinase; FIST; Hipk3; HIPK3_HUMAN; homeodomain interacting protein kinase 3; Homeodomain-interacting protein kinase 3; Homolog of protein kinase YAK1; PKY; RP24 297H17.5; YAK1.
〖浓度〗1mg/1ml
〖规格〗0.2ml/200μg
〖抗体来源〗Rabbit
〖克隆类型〗polyclonal
〖交叉反应〗Fas相互作用蛋白激酶3抗体Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep
〖产品类型〗一抗
〖研究领域〗细胞生物 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶 表观遗传学
〖蛋白分子量〗predicted molecular weight: 134kDa
〖性状〗Lyophilized or Liquid
〖免疫原〗KLH conjugated synthetic peptide derived from human HIPK3
〖亚型〗IgG
〖纯化方法〗affinity purified by Protein A
〖储存液〗Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
〖产品应用〗WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
〖产品介绍〗Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors.
Function : Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Subunit : Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR). Interacts with UBL1/SUMO-1. Binds to NR5A1/SF1, SPEN/MINT and RUNX2.
Subcellular Location : Cytoplasm. Nucleus.
Tissue Specificity : Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.
Post-translational modifications : Autophosphorylated, but autophosphorylation is not required for catalytic activity.
May be sumoylated.
Similarity : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
Contains 1 protein kinase domain.
Database links : UniProtKB/Swiss-Prot: Q9H422.1
做过实验的亲们都知道Fas相互作用蛋白激酶3抗体反应规律,仔细观察我们会发现当抗原第一次进入机体时,需经一定的潜伏期才能产生抗体,且抗体产生的量也不多,在体内维持的时间也较短。当相同抗原第二次进入机体后,开始时,由于原有抗体中的一部分与再次进入的抗原结合,可使原有抗体量略为降低。随后,抗体效价迅速大量增加,可比初次反应产生的多几倍到几十倍,在体内留存的时间亦较长。因此得出由抗原刺激机体产生的抗体,经过一定时间后可逐渐消失。此时若再次接触抗原,可使已消失的抗体快速上升。如再次刺激机体的抗原与初次相同,则称为特异性回忆反应;若与初次反应不同,则称为非特异性回忆反应。
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Ab-(010)-17161 Gamma-Synuclein/SNCG 核突触蛋白-γ抗原 ,规格: 0.5mg ,英文名: Gamma-Synuclein/SNCG
Ab-(010)-17162 SUMO(small ubiquitin-related modifier) 类泛素蛋白抗原 ,规格: 0.5mg ,英文名: SUMO
Ab-(010)-17163 STAT6(signal transducers and activators of transduction 6) 信号转导和转录激活因子6抗原 ,规格: 0.5mg ,英文名: STAT6
Ab-(010)-17164 STAT5(signal transducers and activators of transduction5) 信号转导和转录激活因子5(STAT5)抗原 ,规格: 0.5mg ,英文名: STAT5
Ab-(010)-17165 STAT3(signal transducers and activators of transduction3) 信号转导和转录激活因子3抗原 ,规格: 0.5mg ,英文名: STAT3
Ab-(010)-17166 phospho-STAT1(p-Tyr701) peptide 磷酸化信号转导与转录激活因子1抗原 ,规格: 0.5mg ,英文名: phospho-STAT1
Ab-(010)-17167 STAT1(signal transducers and activators of transcription 1) 信号转导与转录激活因子1抗原 ,规格: 0.5mg ,英文名: STAT1
Ab-(010)-17168 SSTR5 (somatostatin receptor 5) 生长抑素受体5抗原 ,规格: 0.5mg ,英文名: SSTR5
Ab-(010)-17169 SSTR3 peptide 生长抑素受体3抗原 ,规格: 0.5mg ,英文名: SSTR3
Ab-(010)-17170 SSTR2 (somatostatin receptor 2) 生长抑素受体2抗原 ,规格: 0.5mg ,英文名: SSTR2
Ab-(010)-17171 Fut4/CD15/SSEA-1(Stage-specific embryonic surface antigen 1) 阶段特异性胚胎表面抗原-1抗原 ,规格: 0.5mg ,英文名: Fut4/CD15/SSEA-1
Ab-(010)-17172 AKAP12A/SSeCKS peptide 丝氨酸抑制蛋白激酶C底物抗原 ,规格: 0.5mg ,英文名: AKAP12A/SSeCKS
Ab-(010)-17173 SREBP-1(Sterol Regulatory Element Binding Protein-1) 固醇调节元件结合蛋白1抗原 ,规格: 0.5mg ,英文名: SREBP-1
Ab-(010)-17174 SRF(Serum response factor) 血清应答因子抗原 ,规格: 0.5mg ,英文名: SRF
Ab-(010)-17175 SPARC (secreted protein acidic and rich in cysteine) 富含半胱氨酸的酸性分泌蛋白抗原 ,规格: 0.5mg ,英文名: SPARC
Ab-(010)-17176 TSFP1/SP1(transcription factor Sp1) SP1转录生长因子抗原 ,规格: 0.5mg ,英文名: TSFP1/SP1
Ab-(010)-17177 Sox2 胚胎干细胞关键蛋白 ,规格: 0.5mg ,英文名: Sox2
Ab-(010)-17178 Somatostatin/GRIH 生长抑素抗原 ,规格: 0.5mg ,英文名: Somatostatin/GRIH
Ab-(010)-17179 SOD2 (superoxide-dimutase-2) 超氧化物歧化酶2抗原 ,规格: 0.5ml ,英文名: SOD2
Ab-(010)-17180 SOD1(superoxide-dimutase-1) 超氧化物歧化酶1抗原 ,规格: 0.5mg ,英文名: SOD1
Ab-(010)-17181 Socs 3 (suppressor of cytokine signaling 3) 细胞因子信号传导抑制蛋白3抗原 ,规格: 0.5mg ,英文名: Socs
Ab-(010)-17182 Snail Snail蛋白抗原 ,规格: 0.5mg ,英文名: Snail
Ab-(010)-17183 SNAP-25 (synaptosomal-associated protein 25) 突触相关膜蛋白25抗原 ,规格: 0.5mg ,英文名: SNAP-25
Ab-(010)-17184 phosphor-SMAD(p-Ser425)、phosphor-Mothers against decapentaplegic 磷酸化SMAD(p-Ser425)抗原 ,规格: 0.5mg ,英文名: phosphor-SMAD
Ab-(010)-17185 Smad7(Mothers against decapentaplegic homolog 7) Smad 7(多肽) ,规格: 0.5mg ,英文名: Smad7
Ab-(010)-17186 Smad4(Mothers against decapentaplegic homolog 4) Smad4抗原 ,规格: 0.5mg ,英文名: Smad4
Ab-(010)-17187 phospho-Smad2(p-Ser465)petide 磷酸化Smad2抗原 ,规格: 0.5mg ,英文名: phospho-Smad2
Ab-(010)-17188 SMN1(survival of motor neuron 1) 运动神经元生存蛋白1抗原 ,规格: 0.5mg ,英文名: SMN1
Ab-(010)-17189 SLC34A2/NaPi-2b(Solute carrier family 34 member 2) 磷酸钠协同转运蛋白抗原 ,规格: 0.5mg ,英文名: SLC34A2/NaPi-2b
Ab-(010)-17190 SLC33A1(Acetyl-coenzyme A transportor 1) 乙酰辅酶A转运蛋白1抗原 ,规格: 0.5mg ,英文名: SLC33A1
Ab-(010)-17191 Smac/DIABLO(the second mitochondrial activator of caspase) 线粒体促凋亡蛋白抗原 ,规格: 0.5mg ,英文名: Smac/DIABLO
Ab-(010)-17192 Slc4a7/Nbcn1(solute carrier family 4, sodium bicarbonate cotransporter, member 7) 碳酸氢钠协同转运蛋白4-A7抗原 ,规格: 0.5mg ,英文名: Slc4a7/Nbcn1
Ab-(010)-17193 SLC4A4(solute carrier family 4:sodium bicarbonate cotransporter NBC1) 碳酸氢钠协同转运蛋白4-A4 ,规格: 0.5mg ,英文名: SLC4A4
Ab-(010)-17194 Skp2 peptide 细胞S相激酶相关蛋白抗原 ,规格: 0.5mg ,英文名: Skp2
Ab-(010)-17195 SIRT1(sirtuin 1) 沉默调节蛋白1抗原 ,规格: 0.5mg ,英文名: SIRT1
Ab-(010)-17196 SIP1 peptide 运动神经元存活蛋白结合蛋白1抗原 ,规格: 0.5mg ,英文名: SIP1
Ab-(010)-17197 SHP2 peptide 蛋白酪氨酸磷酸酶2抗原 ,规格: 0.5mg ,英文名: SHP2
Ab-(010)-17198 Shiga-like toxin IIe variant subunit A[Escherichia coli 0139] 大肠杆菌志贺样毒素菌体蛋白(O139菌型) ,规格: 0.5mg ,英文名: Shiga-like
Ab-(010)-17199 Shiga-like toxin IIe variant subunit A 0139[Escherichia coli 0139] 大肠杆菌志贺样毒素Ⅱ型突变体(O139菌型) ,规格: 0.5mg ,英文名: Shiga-like
Ab-(010)-17200 Shadow/SPRN(Shadow of prion protein precursor) 新朊蛋白/朊蛋白相关蛋白/沙杜(Shadoo)蛋白抗原 ,规格: 0.5mg ,英文名: Shadow/SPRN
Ab-(010)-17201 SGLT1(sodium-glucose cotransporter1) 钠-葡萄糖共转运载体1抗原 ,规格: 0.5mg ,英文名: SGLT1
Ab-(010)-17202 SFRP1(Secreted frizzled related protein 1) 分泌型卷曲相关蛋白1抗原 ,规格: 0.5mg ,英文名: SFRP1
Ab-(010)-17203 Sema3F (semaphorin 3F) 臂板蛋白3F抗原 ,规格: 0.5mg ,英文名: Sema3F
Ab-(010)-17204 Sema3A (semaphorin 3A) 臂板蛋白3A(多肽) ,规格: 0.5mg ,英文名: Sema3A
Ab-(010)-17205 CXCL16 peptide CXC趋化因子16抗原 ,规格: 0.5mg ,英文名: CXCL16
Ab-(010)-17206 CXCL14(CXC-chemokine ligand 16) CXC趋化因子14抗原 ,规格: 0.5mg ,英文名: CXCL14
Ab-(010)-17207 SCN9A/NAV1.7(Sodium channel protein type 9 subunit alpha) 电压开启的钠离子通道SCN9A抗原 ,规格: 0.5mg ,英文名: SCN9A/NAV1.7
Ab-(010)-17208 SCF (Stem Cell Factor) 干细胞生长因子抗原 ,规格: 0.5mg ,英文名: SCF
Ab-(010)-17209 SATB1(special AT-rich sequence binding protein) 核基质结合区结合蛋白1抗原 ,规格: 0.5mg ,英文名: SATB1
Ab-(010)-17210 S-100A1 (S100 calcium-binding protein A1) 钙结合蛋白S100A1抗原 ,规格: 0.5mg ,英文名: S-100A1
Ab-(010)-17211 S100B(S100 calcium binding protein B)(human, mouse, rat, bovine, Rabbit, chicken) S100B蛋白多肽 ,规格: 0.5mg ,英文名: S100B
Ab-(010)-17212 S100B S100B蛋白抗原 ,规格: 0.5ml ,Fas相互作用蛋白激酶3抗体英文名: S100B
Ab-(010)-17213 S6PDH(NADP sorbitol-6-phosphate dehydrogenase) 6-磷酸山梨醇脱氢酶抗原 ,规格: 0.5mg ,英文名: S6PDH
Ab-(010)-17214 RXR Alpha(retinoid-X receptor alpha) 核受体RXRα抗原 ,规格: 0.5mg ,英文名: RXR
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