供货周期: | 现货 |
品牌: | GenWay |
规格: | 0.1ml/100μg 0.2ml/200μg |
货号: | yy01-0064 |
CAS号: |
泛素样蛋白Sumo2/3抗体形态:液态
抗体纯度: >95% By SDS-PAGE
保存环境:2-8℃ 短期保存或<-20℃长期保存保存 1 年以上,避免反复冻融。
英文名称 Anti-Sumo 2+3
中文名称 泛素样蛋白Sumo2/3抗体
别 名 HSMT3; MGC117191; OTTHUMP00000115275; OTTHUMP00000115276; OTTHUMP00000115277;浓 度 1mg/1ml
泛素样蛋白Sumo2/3抗体规 格 0.1ml/100μg 0.2ml/200μg
我们提供抗体来源有人、小鼠、大鼠、兔等动物,规格多样,全国免邮,我们用更安全的方式方法保存及运输泛素样蛋白Sumo2/3抗体。
本公司专业供应各种进口、国产一抗及二抗,品牌有R&D、Santa Cruz、Bipec、Millipore等国际知名品牌,品种多达7000多种,由于产品的数量众多,产品的宿主、抗原来源及应用范围(WB、IH(F/P)、FC、ELISA、IP、IF等)有所不同。
我们还可以为客户提供BAP31蛋白抗体的纯化和标记服务,具体包括盐析沉淀纯化、Portein A/G纯化、免疫亲和纯化、HRP标记、FITC标记等。
泛素样蛋白Sumo2/3抗体的详细介绍:
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Zebrafish
产品类型 一抗
研究领域 细胞生物 神经生物学 细胞周期蛋白 泛素
蛋白分子量 predicted molecular weight: 10.9+10.5kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Sumo 2+3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
REG-4(Human regenerating gene IV ) ELISA Kit 人再生基因蛋白IV Multi-class antibodies
VS(Human versican/PG-M/PG-350) ELISA kit 人多功能蛋白聚糖 Multi-class antibodies
Nfkbie(Human nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor epsilon) KLISA Kit 人B细胞κ 轻肽基因增强子核因子抑制因子ε Multi-class antibodies
ADAMTS4(Human ADAM metallopeptidase with thrombospondin type 1 motif4) ELISA Kit 人ADAM金属肽酶含血小板反应蛋白1基元4 Multi-class antibodies
Human similar to RIKEN cDNA 4933429F08 gene ELISA Kit 人类似RIKEN cDNA 4933429F08 基因 Multi-class antibodies
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
泛素样蛋白Sumo2/3抗体保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease.
Function : SUMO proteins, such as Sumo 2 and Sumo 3, post-translationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. Sumo 2 and Sumo 3 are highly homologous, hence it is very difficult to produce antibodies which distinguish them.
Subunit : Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains).
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