供货周期: | 现货 |
品牌: | CST |
规格: | g/mg |
货号: | XY-0802R |
CAS号: |
乳腺癌易感基因1抗体(人)
产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
乳腺癌易感基因1抗体(人)产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 (石蜡切片需做抗原修复)
乳腺癌易感基因1抗体(人)产品介绍
BRCA1基因是最早被发现的乳腺癌易感基因其突变和家族性乳腺癌、卵巢癌的发病有关。
bs-0803R 用于检测mo, rat的BRCA1
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. Transcript Variant: This variant (BRCA1a') uses different splice site in the 5' UTR when compared to variant BRCA1a. It encodes the full-length BRCA1 protein (isoform 1) which is also known as p220. Variants BRCA1a and BRCA1b also encode the full-length BRCA1 protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
mol wt:205kDa
Other Aliases:
BRAC 1; BRCA 1; BRCC 1; BRCC1; Breast Cancer 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; Breast Ovarian Cancer Susceptibility; IRIS; Papillary Serous Carcinoma Of The Peritoneum; PSCP; RING finger protein 53; RNF53
乳腺癌易感基因1抗体(人)
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xy-9619R C15orf4115号染色体开放阅读框41抗体
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xy-3098R Phospho-Connexin 43 (Ser368)磷酸化Connexin 43蛋白抗体
xy-2759R cofilin丝切蛋白抗体
xy-3100R phospho-Cortactin (Tyr466)磷酸化皮层肌动蛋白抗体
xy-3122R Phospho-Cyclin B1 (Ser147)磷酸化周期素B1抗体
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