钙激活的中性蛋白酶2抗体

钙激活的中性蛋白酶2抗体

产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

钙激活的中性蛋白酶2抗体产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

钙激活的中性蛋白酶2抗体产品介绍

    钙蛋白酶2(calpain2)也是一族钙离子依赖性的、水解半胱氨酸的蛋白酶,广泛存在于全身各脏器组织中。钙蛋白酶参与不同细胞过程,包括细胞骨架和细胞膜附着的构型重建、不同的信号转导途径和细胞凋亡等。

    Mu Calpain, and m calpain, also known as Calpain 2, are intracellular, calcium dependent cysteine proteases. Mu calpain has a micromolar sensitivity (thus the mu) as compared to the millimolar calcium sensitivity of m calpain. Both Calpains 1 and 2 are composed of an 80 kD subunit and a 30 kD subunit. Whereas the 30 kDa subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca++ requirements that are suggested by their names. 
    The calpains have papain like activity, thus the pain nomenclature. Both Calpain 1 and Calpain 2 are ubiquitously expressed, and are countered by the endogenous calpain inhibitor, calpastatin. 
    Other calpain family members (calpain 94, ncl2, ncl3, etc) have more limited tissue distribution, and perhaps different functions. The calpain family members consist of a common small subunit (Calpain 4), and a large variable subunit. It is not clear that all calpains contain a small subunit. Domains in the large subunit include the amino terminal domain I, the proteinase domain II, domain III, and the EF hand domain IV. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.
    mol wt:77kDa 
    Other Aliases: 
    Calcium activated neutral proteinase 2; Calcium activated neutral proteinase; CALP80; Calpain 2 (m/II) large subunit; Calpain 2 catalytic subunit; Calpain 2 large catalytic subunit; Calpain 2 large subunit; Calpain large polypeptide L2; Calpain M type; Calpain2; CANP 2; CANP L2; CANP2; CANPL 2; CANPL2; CANPml; Capa2; CAPN 2; CAPN2; FLJ39928; M calpain; M calpin; M type; mCANP; Millimolar calpain

xy-0315R FGL2凝血酶原酶(纤维介素)抗体

xy-0810R Fibulin 5衰老关键蛋白抗体

钙激活的中性蛋白酶2抗体

xy-0119R FLIP凋亡调节基因之一抗体

xy-1120R FLIP凋亡调节基因之一抗体（短型）

xy-0666R Fibronectin纤维连接蛋白抗体

xy-1170R FOS BFosB蛋白抗体

xy-1188R FRA2FRA2/FOSL2抗体

xy-0269R FoxP3叉头蛋白P3抗体

xy-0735R FGF8成纤维细胞生长因子8抗体

xy-6848R Fascin肌动蛋白结合蛋白Fascin抗体

xy-7646R FIS1线粒体裂变1蛋白抗体

xy-1275R FoxP1叉头蛋白P1抗体

xym-1265M F1 protein (YERSINIA PESTIS)鼠疫F1蛋白/鼠疫耶尔森氏菌荚膜抗原F1单克隆抗体

xy-1257R FGF5纤维母细胞生长因子5抗体

xy-6876R FMR1脆性X综合征相关蛋白AFF1抗体

xy-11010R FAM84A感觉神经蛋白1抗体

xy-9601R Frataxin线粒体型共济失调蛋白抗体

xy-8514R Fc ε RIαFC段IgE受体α多肽抗体

xy-8654R FAM81AFAM81A蛋白抗体

xy-9657R FAM78BFAM78B蛋白抗体

xy-9656R C9orf599号染色体开放阅读框59抗体

xy-9658R FAM76AFAM76A蛋白抗体

xy-9659R FAM76BFAM76B蛋白抗体

xy-11011R FAM92A1FAM92A1蛋白抗体

xy-11012R FAM98AFAM98A蛋白抗体

xy-8237R FRMD5FRMD5蛋白抗体

xy-8238R FRMD6FRMD6蛋白抗体

xy-8216R FAM161AFAM161A蛋白抗体

xy-8221R FAM153BFAM153B蛋白抗体

xy-8198R FAM46CFAM46C蛋白抗体

xy-8199R TCRP1舌癌化疗耐药相关蛋白1

xy-8205R FAM129BFAM129B蛋白抗体

xy-8206R RMD2微管动力调节蛋白2抗体

xy-8208R FAM50AFAM50A蛋白抗体

xy-8213R FAM113AFAM113A蛋白抗体

xy-8219R FAM150AFAM150A蛋白抗体

xy-8240R FRMD8FRMD8蛋白抗体