供货周期: | 现货 |
品牌: | CST |
规格: | g/mg |
货号: | XY-1961R |
CAS号: |
ABI1/SSH3BP1蛋白抗体
产品类别
兔抗人、大、小鼠ABI1/SSH3BP1蛋白抗体
ABI1/SSH3BP1蛋白抗体
产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 (石蜡切片需做抗原修复)
ABI1/SSH3BP1蛋白抗体
产品介绍
May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus(v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA (By similarity). Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.
mol wt:56kDa(human), 53kDa(mo, rat)
Other Aliases:
Abelson interactor 1; Abelson interactor 1; ABI 1; ABI1; Abl binding protein 4; Abl interactor 1; Abl interactor protein 1 long; AblBP4; Ablphilin 1; E3B1; Eps8 binding protein; Eps8 SH3 domain binding protein; Hssh3bp1; NAP1; NAP1BP; Spectrin SH3 domain binding protein 1; SSH3BP; SSH3BP1
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