供货周期: | 现货 |
品牌: | CST |
规格: | g/mg |
货号: | XY-2440R |
CAS号: |
白介素-1受体相关激酶4抗体
产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
白介素-1受体相关激酶4抗体产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 (石蜡切片需做抗原修复)
白介素-1受体相关激酶4抗体产品介绍
Interleukin 1 (IL1) and lipopolysaccharide (LPS) induces cellular responses through IL1 receptor (IL1R) and Toll like receptors (TLR). IL1R associated kinases (IRAK, IRAK2, and IRAKM) regulate the activation of NF-kB and MAP kinase (MAPK) by IL1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK4. Overexpression of IRAK4 activates NF-kB and MAPK pathways. IRAK4 interacts with and phosphorylates IRAK1. IRAK4 deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL1R/TLR mediated inflammatory responses and in innate immunity.
mol wt:51kDa
Other Aliases:
8430405M07Rik, 9330209D03Rik, IPD1, IRAK4, NY-REN-64, REN64, INTERLEUKIN RECEPTOR-ASSOCIATED KINASE 4
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