| 供货周期： | 一周 |
| 品牌： | Abcam |
| 规格： | 多种抗体规 |
| 货号： | YY-Ab-3513 |
| CAS号： | 详见产品说明 |
神经纤毛蛋白1抗体
[别名：Neuropilin-1; NRP-1; Neuropilin1; Neuropilin 1; BDCA4; CD 304; CD304; DKFZp686A03134; DKFZp781F1414; NEL like protein 1; Nel related protein 1; Neuropilin1; Neuropilin 1; Neuropilin1 transmembrane receptor; NP1; NRP 1; NRP; NRP1; OTTHUMP00000020818; OTTHUMP00000020820; OTTHUMP00000020821; Vascular endothelial cell growth factor 165 receptor; VEGF165R.
[产品介绍：神经纤毛蛋白1抗体Neuropilin 1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both Vascular Endothelial Growth Factor and Semaphorin family members. Neuropilin 1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.
Function : The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
Subunit : Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1.
Subcellular Location : Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.
Tissue Specificity : The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.
Similarity : Belongs to the neuropilin family.
Contains 2 CUB domains.
Contains 2 F5/8 type C domains.
Contains 1 MAM domain.
CD304是一种神经元受体，被认为表达于众多的非造血细胞上，包括神经元、内皮细胞和肿瘤细胞。在体外单核细胞和造血前体细胞衍生的CD1a+树突状细胞是CD304（BDCA-4/Neuropilin-1）。
与CD303(BDCA-2)一样，CD304(BDCA-4)抗原特异性地表达于人血液和骨髓中的浆样树突状细胞。与CD303(BDCA-2)不同的是，CD304(BDCA-4)在培养的浆样树突状细胞上表达上调，同时在培养的髓系细胞能被诱导表达。在感染的扁桃体中，CD304(BDCA-4)不仅表达于浆样树突状细胞，而且在其它细胞上也能检测到，如初级滤泡B辅助性记忆T细胞。
规格：多种抗体规格提供
贮存： 贮存于-20℃
纯化方法：亲和纯化的蛋白
研究领域：细胞生物 免疫学 锌指蛋白
产品应用比例：WB=1:100-500 Elisa=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1/20-1/100
公司生产的神经纤毛蛋白1抗体每个流程都执行严格的检测标准，保证蛋白抗原产品质量，质量稳定，实验效果明显。按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类。公司产品经无数次市场验证，若出现质量问题可无条件换货或退货。本司备有上万种产品，所有生化试剂产品都具有价格绝对优势，质量保证，欢迎新老客户垂询！
