供货周期: | 7天 |
品牌: | 子起生物 |
型号: | 咨询客服 |
货号: | 029-16361 |
CAS号: | 咨询客服 |
Wako 029-16361 BF-168 和光纯药 现货
【产品名称】BF-168,
Wako 029-16361 BF-168 和光纯药 现货
【制造商】Wako Pure Chemical Industries, Ltd.
【销售商代码】029-16361
【规格】1mg
【价格】
【分子式】C18H17FN2O2
【分子量】312.34
【保存条件】Keep at RT.
Wako 029-16361 BF-168 和光纯药 现货
【外观】Keep at -20 degrees C.
【注意事项】This product is for research use on
for Alzheimer's Disease (AD)
BF-168 (Wako Cat. #029-16361): Senile plaque-selective fluorescent probe
BF-168 is a probe for senile plaques (SPs). It selectively binds SPs in AD brain sections and recognizes Aβ 1-42 positive diffuse plaques.
BF-170 (Wako Cat. #026-16371): Neurofibrillary tangle change-selective fluorescent probe BF-170 is a probe for neurofibrillary tangles (NFTs). It exhibits greater binding affinity to Tau fibrils such as NFTs, neuropil threads and paired helical filament than to Aβ fibrils.
Wako 029-16361 BF-168 和光纯药 现货
B-168
Solubility: Soluble in methanol and ethanol.
λex: 380 ~ 420 (nm)
λem: > 450 (nm)
Procedure:
Deparaffinize the section on 1 slide glass plate.
Immerse the section with 10% formalin neutral buffer for 60 minutes.
Wako 029-16361 BF-168 和光纯药 现货
Wash the section with PBS for 5 minutes.
Blanch the section with 0.25% potassium permanganate solution for 20 minutes.
Wash the section twice with PBS for 2 minutes.
Immerse the section with 0.1% potassium metabisulfite and 0.15% oxalic acid for seconds.
Wash the section three times with PBS for 2 minutes.
Immerse the quenched tissue section with 100 μmol/L BF-168 solution containing 50% ethanol for 10 minutes.
Dip the section 5 times with water for a few seconds.
Observe the section with fluorescence microscope.
Wako 029-16361 BF-168 和光纯药 现货
References:
Kitamoto, T., Ogomori, K., Tateishi, J., and Prusiner, S. B.: Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids., Lab. Invest., 57, 230-236 (1987)
Okamura, N., et al.: Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain, J. Neurosci., 24, 2535-2541 (2004)
Okamura, N., Kudo, Y., et al.: Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease, J. Neurosci., 25, 10857-10862 (2005)
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