硒蛋白W抗体elisa实验

英文名称  Anti-Selenoprotein W 

中文名称  硒蛋白W抗体 

 硒蛋白W抗体别    名  MGC105482; SelW; SEPW1; Selenoprotein W; SELW_RAT. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Sheep  

产品类型  一抗    

研究领域  细胞类型标志物  

蛋白分子量  predicted molecular weight: 9.5kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human Selenoprotein W N-terminus 

亚    型  IgG 

 硒蛋白W抗体纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein has been shown to function as a glutathione-dependent antioxidant in vivo. It is highly expressed in proliferating myoblasts and suggested to be involved in muscle growth and differentiation by protecting the developing myoblasts from oxidative stress.  硒蛋白W抗体[provided by RefSeq].

Function : Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity).

Subunit : Interacts with DPYSL2, PRDX1, YWHAB, YWHAG, HSP70 and HSP90 (By similarity).

Subcellular Location : Cytoplasm.

Tissue Specificity : Ubiquitously expressed with highest levels in skeletal muscle and heart, moderate levels in brain, spinal cord, thyroid, spleen, prostate, ovary, small intestine and colon, and lowest levels in liver and lymph node.

Similarity : Belongs to the SelWTH family. SELW subfamily.

Database links : UniProtKB/Swiss-Prot: P63301.3

硒蛋白-W（selenoprotein W）和一种存在于多种组织中的18ku硒蛋白P（18ku selenoprotein）。它们具有防止膜结构及生物大分子的氧化损伤；合成并调节DNA表达；促进精子生成、发育及维持其活力；保护内皮细胞和维护肌肉组织的正常功能等广泛的生理作用。该蛋白与人、羊有部分交叉。