供货周期: | 现货 |
品牌: | WAKO |
型号: | 0.1ml/100μg 0.2ml/200μg |
货号: | YS-0822 |
英文名称 Anti-Secretin receptor
中文名称 分泌素受体抗体
分泌素受体抗体别 名 6530402O03Rik, MGC102218, MGC93381, SCTR, SR; Secretin receptor; SCT-R; SCTR_HUMAN.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep
产品类型 一抗
研究领域 信号转导 生长因子和激素 细胞膜受体 内分泌病 细胞类型标志物
蛋白分子量 predicted molecular weight: 46kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from the middle of human Secretin receptor
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
分泌素受体抗体产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分泌素受体抗体保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The receptor for secretin is a class 2 (or class B) G protein coupled receptor that signals through Gs to stimulate cAMP production. Along with its traditional role in the pancreas, studies in secretin-deficient mice have shown miscommunication between the CA3 Schaffer collateral and CA1 pyramidal neurons, causing a deficiency in synaptic transmission. This miscommunication of CA1 dendrites is found in Autism, Rett Syndrome, and most forms of mental retardation, suggesting secretin could be a potential target for treatment of these disorders.
Function : This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular Location : Cell membrane; Multi-pass membrane protein.
Similarity : Belongs to the G-protein coupled receptor 2 family.
Database links : UniProtKB/Swiss-Prot: P47872.2
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