供货周期: | 现货 |
品牌: | GenWay |
规格: | 0.1ml/100μg 0.2ml/200μg |
货号: | YS-2145 |
CAS号: |
英文名称 Anti-5HT3D + 5HT3E Receptor
中文名称 5-羟色胺受体3D+3E抗体
5-羟色胺受体3D+3E抗体别 名 5 HT3 D; 5 HT3 E; 5 HT3c1; 5 HT3D; 5 HT3E; 5 hydroxytryptamine (serotonin) receptor 3 family member D; 5 hydroxytryptamine (serotonin) receptor 3 family member E; 5 hydroxytryptamine receptor 3 subunit D; 5 hydroxytryptamine receptor 3 subunit E; 5 hydroxytryptamine receptor 3D; 5 hydroxytryptamine receptor 3E; 5HT3D; HTR3D; HTR3E; MGC119636; MGC119637; MGC120035; MGC120036; MGC120037; Serotonin 5 HT 3D receptor; Serotonin receptor 3D; Serotonin receptor 3E; 5HT3D_HUMAN; 5HT3E_HUMAN.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human
产品类型 一抗
研究领域 神经生物学 细胞膜受体 G蛋白偶联受体 新陈代谢 G蛋白信号
蛋白分子量 predicted molecular weight: 48kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human 5HT3D + 5HT3E Receptor
5-羟色胺受体3D+3E抗体亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Serotonin is a monoamine neurotransmitter that is made in serotonergic neurons in the CNS (central nervous system) and is important in the regulation of mood, sleep, vomiting, sexuality and appetite. 5-HT3 (5-hydroxytryptamine-3) receptor is the only ligand-gated ion channel within the family of serotonin receptors. It is composed of five subunits consisting of SR-3A, SR-3B, HTR3C, HTR3D and HTR3E. HTR3D (5-hydroxytryptamine receptor 3D), also known as Serotonin receptor 3D, is a 454 amino acid multi-pass membrane protein that is one components of the pentaheteromeric complex that forms the 5-HT3 receptor. HTR3D must be co-expressed with SR-3A to form a functional 5-HT3 receptor complex on the plasma membrane. Until it is complexed with SR-3A, HTR3D is localized within the endoplasmic reticulum. Expression of HTR3D is restricted to kidney, colon and liver. There are three different isoforms of HTR3D that are expressed as a result of alternative splicing events.
Function : 5HT3D Receptor and 5HT3E Receptor are receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The receptors form a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
5-羟色胺受体3D+3E抗体Subunit : Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.
Subcellular Location : Cell membrane; Multi-pass membrane protein. Note: Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
Tissue Specificity : Expressed in liver, as well as fetal and adult colon and kidney.
Similarity : Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3D sub-subfamily.
Database links : UniProtKB/Swiss-Prot: Q70Z44.3 UniProtKB/Swiss-Prot: A5X5Y0.1
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