骨形态发生蛋白10抗体elisa实验|0.1ml/100μg 0.2ml/200μg|BJ-3839-上海邦景实业有限公司

骨形态发生蛋白10抗体elisa实验

参考价：面议

供货周期：

现货

品牌：

GenWay

规格：

0.1ml/100μg 0.2ml/200μg

货号：

BJ-3839

CAS号：

产品详情

骨形态发生蛋白10抗体英文名称 Anti-BMP10

中文名称 骨形态发生蛋白10抗体

别名 BMP-10; Bmp10; BMP10_HUMAN; Bone morphogenetic protein 10; Bone morphogenetic protein 10 preproprotein; MGC126783.

浓度 1mg/1ml

规格 0.2ml/200μg

抗体来源 Rabbit

骨形态发生蛋白10抗体克隆类型 polyclonal

交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep

产品类型一抗

研究领域心血管细胞生物信号转导生长因子和激素

蛋白分子量 predicted molecular weight: 12kDa

性状 Lyophilized or Liquid

免疫原 KLH conjugated synthetic peptide derived from human BMP10

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Bone morphogenic proteins (BMPs) are members of the TGF beta superfamily and are involved in the induction of cartilage and bone formation. BMP-10 (Bone morphogenetic protein 10) is a 424 amino acid secreted protein that exists as a disulfide-linked homodimer. Expressed specifically in heart tissue, BMP-10 functions to prevent the premature activation of p57 (a negative cell cycle regulator), thereby maintaining the proliferative activity of embryonic cardiomyocytes and playing a critical role in the formation of trabeculae within the developing heart. Additionally, BMP-10 inhibits the growth and migration of endothelial cells and functions as a ligand for ALK-1, a protein that is tightly linked to angiogenesis. This suggests that, in addition to its role in cardiomyocyte formation, BMP-10 participates in the formation of blood vessels in developing cardiac muscle.

骨形态发生蛋白10抗体Function : Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.

Subunit : Homodimer; disulfide-linked (By similarity).

Subcellular Location : Secreted.

Similarity : Belongs to the TGF-beta family.

Database links : UniProtKB/Swiss-Prot: O95393.1