磷酸化β 连环素蛋白抗体

磷酸化β 连环素蛋白抗体

英文名称    phospho-beta catenin (Tyr142)    

中文名称    磷酸化β 连环素蛋白抗体    

别    名    beta Catenin (phospho Y142); Beta catenin(phospho Tyr142); p-beta Catenin (Y142); p-Beta catenin(Tyr142); beta-catenin; beta catenin; CTNNB1; CHBCAT; CTNNB1; CTNNB; PRO2286; Cadherin associated protein; Catenin (cadherin associated protein), beta 1, 88kDa; Catenin beta 1; Catenin beta-1; CATNB; CTNB1_HUMAN; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923; b-catenin; OTTHUMP00000162082; OTTHUMP00000165222; OTTHUMP00000165223; OTTHUMP00000209288; OTTHUMP00000209289; Catenin-β; Catenin β.       

产品类型    磷酸化抗体     

研究领域    肿瘤  心血管  细胞生物  神经生物学  信号转导  干细胞  细胞凋亡  细胞骨架      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken,     

产品应用    ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    86kDa    

细胞定位    细胞核 细胞浆 细胞膜 细胞外基质     

性    状    Lyophilized or Liquid    

浓    度    1mg/ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human Beta catenin around the phosphorylation site of Tyr142:IN(p-Y)QD     

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

PubMed    PubMed    

产品介绍    The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009].    

细胞粘附蛋白（Call Adhesion Protein）
β连环素蛋白β-catenin是一种多功能的蛋白质，能链接E-\N-,钙粘附分子具有参与细胞粘附和介导信号转导的双重功能，并与肿瘤的发生发展及浸润密切相关。
在正常个体中，β-catenin和钙黏蛋白形成复合体，介导同型细胞的粘附，维持细胞的稳定；同时，β-catenin作为Wnt/β-catenin信号通路的关键成员在介导信号转导过程中调控细胞的增殖和凋亡。
在恶性肿瘤中，β-catenin的表达呈现明显的异质性，促使细胞异常增殖，还可使细胞之间的黏附性减弱，侵袭性增强。