环腺苷酸应答元件结合蛋白抗体

报价:¥1580
供货周期: 现货
品牌: LMAI Bio
型号: 50ul/100ul/200ul
货号: LM20704R
上海联迈生物工程有限公司
银牌会员7年生产商
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环腺苷酸应答元件结合蛋白抗体

 

英文名称    CREB-1    

中文名称    环腺苷酸应答元件结合蛋白抗体    

别    名    Active transcription factor CREB; cAMP response element binding protein; cAMP responsive element binding protein 1; CREB1; CREB 1; CREB1; MGC9284; Transactivator protein; CREB; CREB1_HUMAN.      

研究领域    免疫学  染色质和核信号  信号转导  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:500-2000 ELISA=1:500-1000 Flow-Cyt=1μg/Test  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    37kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/ml    

免 疫 原    KLH conjugated synthetic peptide derived from human CREB-1:51-120/341     

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

PubMed    PubMed    

产品介绍    Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB appears to play an important role in learning and memory. CREB knock out mice show diminished learning ability.    

环腺苷酸应答元件结合蛋白(cAMP responsive element binding protein, CREB)是真核细胞转录因子,属于ATF/CREB家族。参与由cAMP或某些病毒蛋白质所诱导基因转录的调节。

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环腺苷酸应答元件结合蛋白抗体由上海联迈生物工程有限公司为您提供,货号LM20704R,规格:50ul/100ul/200ul,CAS号:,如您想了解更多关于环腺苷酸应答元件结合蛋白抗体价格、环腺苷酸应答元件结合蛋白抗体结构式、批发、用途等信息,欢迎咨询。除供应环腺苷酸应答元件结合蛋白抗体外,还可为您提供胰岛素样生长因子1抗体、酪氨酸羟化酶抗体等试剂,公司有专业的客户服务团队,是您值得信赖的合作伙伴,LMAI-BIO客户服务电话400-860-5168转4246,售前、售后均可联系。
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