肝细胞生长因子受体抗体

肝细胞生长因子受体抗体

英文名称    Met (c Met)    

中文名称    肝细胞生长因子受体抗体    

别    名    AUTS9; c met; cmet; c-Met; D249; Hepatocyte growth factor receptor; Hepatocyte growth factor receptor Precursor; HGF; HGF receptor; HGF SF receptor; HGF/SF receptor; HGFR; MET; Met proto oncogene tyrosine kinase; Met proto-oncogene (hepatocyte growth factor receptor); Met proto-oncogene; Met protooncogene; MET_HUMAN; Oncogene MET; Par4; Proto-oncogene c-Met; RCCP2; Renal cell carcinoma papillary 2 gene; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met.      

研究领域    肿瘤  细胞生物  免疫学  染色质和核信号  信号转导  转录调节因子  激酶和磷酸酶  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,     

产品应用    WB=1:500-2000 ELISA=1:500-1000 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    153kDa    

细胞定位    细胞膜 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Met (c Met):301-400/1390 <Extracellular>    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

PubMed    PubMed    

产品介绍    c-Met, a member of the tyrosine kinase superfamily, is the receptor for hepatocyte growth factor, also known as scatter factor (HGF/SF). The mature c-Met protein is a disulfide-linked heterodimer with Mr=190 kDa composed of a heavily glycosylated alpha subunit that is completely extracellular in localization, and a beta subunit comprising an extracellular ligand binding domain, a single transmembrane domain, and a cytoplasmic tyrosine kinase domain. Cells expressing c-Met include epithelial cells, endothelial cells, blood cells of various types, and glomerular mesenchymal cells.    

细胞膜受体（Membrane Receptors) 
c-Met蛋白是肝细胞生长因子受体（Hepatocyte growth factor receptor, HGFR），又称受体蛋白酪氨酸激酶，肝细胞生长因子和过度表达的c-Met(HGFR)蛋白结合，在肿瘤的发生、进展和血管形成中都起着重要作用。
c-met蛋白也是HGF特异性受体，具有内源性酪氨酸激酶的活性，HGF与c-met蛋白特异性结合对肿瘤细胞生长、分化及恶性转化可能具有重要的关联。