孤儿核受体PAR1抗体|50ul/100ul/200ul|LM2334R-上海联迈生物工程有限公司

孤儿核受体PAR1抗体

参考价：¥1580

供货周期：

现货

品牌：

LMAI Bio

规格：

50ul/100ul/200ul

货号：

LM2334R

CAS号：

产品详情

孤儿核受体PAR1抗体

英文名称 PXR

中文名称孤儿核受体PAR1抗体

别名 BXR; NR1I2; Nuclear receptor subfamily 1 group I member 2; ONR 1; ONR1; Orphan nuclear receptor PAR 1; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR 1; PAR 2; PAR; PAR q; PAR1; PAR2; PARq; Pregnane X receptor; PRR; SAR; Steroid and xenobiotic receptor; SXR.

研究领域肿瘤细胞生物免疫学染色质和核信号转录调节因子

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Pig, Cow, Horse,

产品应用 WB=1:500-2000 ELISA=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 48kDa

细胞定位细胞核

性状 Lyophilized or Liquid

浓度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human PXR:51-150/434

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed

产品介绍 The human nuclear pregnane X receptor (PXR) activates cytochrome P450-3A expression in response to a wide variety of xenobiotics and plays a critical role in mediating dangerous drug-drug interactions. The human PXR is related to the mouse Pxr1, which they had cloned and shown to be activated by dexamethasone, pregnenolone 16-alpha-carbonitrile (PCN), and other compounds known to induce expression of the CYP3A1 gene, the predominant form of CYP3A in rat liver and intestine. Northern blot analysis detected most abundant expression in liver, colon, and small intestine; transcripts of 2.6, 4.3, and 5 kb were present in each of these tissues.