供货周期: | 现货 |
品牌: | LMAI Bio |
规格: | 50ul/100ul/200ul |
货号: | LM3026R |
CAS号: |
磷酸化腺苷单磷酸活化蛋白激酶β1抗体
英文名称 phospho-AMPK beta 1 (Ser108)
中文名称 磷酸化腺苷单磷酸活化蛋白激酶β1抗体
别 名 PRKAB1(phospho S108); PRKAB1(phospho-S108); AMPK beta 1(Ser108); p-AMPK beta 1(Ser108); p-AMPK beta 1(S108); 5 AMP activated protein kinase subunit beta 1; AMPK; AMPK beta 1 chain; AMPKb; HAMPKb; PRKAB1; 5'-AMP-activated protein kinase subunit beta-1; AMP-activated protein kinase beta subunit; protein kinase, AMP-activated, noncatalytic, beta-1; AMPK beta -1 chain; 5'-AMP-activated protein kinase beta-1 subunit; AMPKb; AMPK subunit beta-1; AAKB1_RAT; AAKB1_HUMAN; AMPK b1; AMPK-b1.
产品类型 磷酸化抗体
研究领域 肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat,
产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=2ug/Test IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 30kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from rat AMPK beta 1 around the phosphorylation site of Ser108:TR(p-S)QN
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008].
AMPKβ1(AMP-activated Protein Kinase beta-1)(腺苷单磷酸活化蛋白激酶β-1)是一种参与细胞适应能量危机的应激反应酶,AMPK不仅可以在细胞水平作为能量的感受器,还可以通过激素和细胞因子,如瘦素、脂联素和ghrelin来参与调节机体的能量消耗和能量摄入.
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