磷酸化组蛋白H3抗体

磷酸化组蛋白H3抗体

英文名称    Phospho-Histone H3 (Ser28)    

中文名称    磷酸化组蛋白H3抗体    

别    名    Histone H3 (phospho S28); p-Histone H3 (phospho S28); Phospho-Histone H3(Ser28); Histone H3(Phospho-Ser28); Histone H3(p-Ser28); Histone H3.3 (phospho S28); Histone H3(Phospho-S28); H3 histone family member E pseudogene; H3F3; HIST3H3; Histone H3 3 pseudogene; H31_TETTH; Histone H3; H3S; Histone H3-I/H3-II; Major histone H3; H3F; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l.      

产品类型    磷酸化抗体     

研究领域    肿瘤  免疫学  染色质和核信号  信号转导  转录调节因子  细胞类型标志物  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Rabbit, Fruit Fly,     

产品应用    WB=1:500-2000 ELISA=1:500-1000 Flow-Cyt=1μg /Test  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    15kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human Histone H3 around the phosphorylation site of Ser28:RK(p-S)AP     

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

PubMed    PubMed    

产品介绍    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]    

蛋白的基因非常保守,在亲缘关系较远的种属中, 四种组蛋白(H2A、H2A、H3、H4)氨基酸序列都非常相似, 如海胆组织H3的氨基酸序列与来自小牛胸腺的H3的氨基酸序列间只有一个氨基酸的差异, 小牛胸腺的H3的氨基酸序列与豌豆的H3也很相似。组蛋白是细胞核内的一种碱性核蛋白，抗组蛋白抗体即是以组蛋白为靶抗原的一种自身，是抗核抗体的一种.主要与药物性红斑狼疮、系统性红斑狼疮、类风湿关节炎有关