磷酸化转化生长因子β活化激酶1

报价:¥1580
供货周期: 现货
品牌: LMAI Bio
型号: 50ul/100ul/200ul
货号: LM3435R
上海联迈生物工程有限公司
银牌会员7年生产商
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磷酸化转化生长因子β活化激酶1

 

英文名称    Phospho-TAK1 (Ser412)    

中文名称    磷酸化转化生长因子β活化激酶1    

别    名    TAK1(Phospho S412); TAK1(Phospho Ser412); MAP3K7; Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1; MAP3K 7; MAPKKK7; Mitogen activated protein kinase kinase kinase 7; TAK1; TGF beta activated kinase 1; TGF1a; Transforming growth factor beta activated kinase 1; M3K7_HUMAN; Map3k7; MEKK7; TGF-beta-activated kinase 1; TGF1a; Transforming growth factor-beta-activated kinase 1.      

产品类型    磷酸化抗体     

研究领域    肿瘤  细胞生物  免疫学  信号转导  细胞凋亡  转录调节因子  激酶和磷酸酶      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Cow, Horse, Rabbit,     

产品应用    WB=1:500-2000 ELISA=1:500-1000  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    64kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from mouse TAK1 around the phosphorylation site of Ser412:RR(p-S)IQ     

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

PubMed    PubMed    

产品介绍    TAK1 (or MAP3K7) was shown to participate in regulation of transcription by transforming growth factor beta (TGF beta). TAK1 is stimulated in response to TGF beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF beta superfamily members. TAB1 and TAB2 are TAK1 binding proteins that may function as activators of the TAK1 (TGF b activated kinase 1) MAPKKK in TGF b signal transduction. TAB1 induced TAK1 activation promoted the dissociation of active forms of IKKa and IKK b from active TAK1, whereas the IKK mutants remained to interact with active TAK1. TNF a activated endogenous TAK1, and the kinase negative TAK1 acted as a dominant negative inhibitor against TNF a induced NFkB activation. TAK1 was suggested to act as a regulatory kinase of IKKs.
   


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磷酸化转化生长因子β活化激酶1由上海联迈生物工程有限公司为您提供,货号LM3435R,规格:50ul/100ul/200ul,CAS号:,如您想了解更多关于磷酸化转化生长因子β活化激酶1价格、磷酸化转化生长因子β活化激酶1结构式、批发、用途等信息,欢迎咨询。除供应磷酸化转化生长因子β活化激酶1外,还可为您提供胰岛素样生长因子1抗体、细胞色素C抗体等试剂,公司有专业的客户服务团队,是您值得信赖的合作伙伴,LMAI-BIO客户服务电话400-860-5168转4246,售前、售后均可联系。
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