供货周期: | 现货 |
品牌: | LMAI Bio |
型号: | 50ul/100ul/200ul |
货号: | LM3657R |
半胱氨酸蛋白酶8相关蛋白2抗体
英文名称 FLASH
中文名称 半胱氨酸蛋白酶8相关蛋白2抗体
别 名 CASP 8 associated protein 2; CASP8 associated protein 2; CASP8AP2; Caspase 8 associated protein 2; CED 4; CED4; FLASH homolog; FLASH homolog RIP 25; FLASH homolog RIP25; FLICE associated huge; FLICE associated huge protein; FLICE-associated huge protein; RIP 25; RIP25; AA387232; D4Ertd659e; mKIAA1315; C8AP2_HUMAN; CASP8-associated protein 2; FLICE-associated huge protein; FLJ11208; KIAA1315; OTTMUSP00000005125; RP23-69G24.1.
研究领域 肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse,
产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 218kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FLASH/CASP8AP2:1861-1982/1982
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.
Studies of FLASH protein suggested that this protein may be a component of the death inducing signaling complex that includes Fas receptor, Fas binding adapter FADD, and caspase 8, and plays a regulatory role in Fas mediated apoptosis.
CASP8AP2是一种与ced4具有同源结构域的蛋白,能诱导肿瘤细胞的凋亡。
详细地址
联系电话
关注
拨打电话
留言咨询