核抑制蛋白磷酸酶1抗体|50ul/100ul/200ul|LM3658R-上海联迈生物工程有限公司

核抑制蛋白磷酸酶1抗体

参考价：¥1580

供货周期：

现货

品牌：

LMAI Bio

规格：

50ul/100ul/200ul

货号：

LM3658R

CAS号：

产品详情

核抑制蛋白磷酸酶1抗体

英文名称 NIPP1

中文名称核抑制蛋白磷酸酶1抗体

别名 Activator of RNA decay; ARD 1; ARD1; Homolog of E.coli RNase E; NIPP 1; NIPP1; Nuclear inhibitor of protein phosphatase 1; Nuclear subunit of PP1; PPP1R8; Protein phosphatase 1 regulatory inhibitor subunit 8; Protein phosphatase 1 regulatory subunit 8; RNase E.

研究领域肿瘤免疫学信号转导细胞凋亡转录调节因子激酶和磷酸酶

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Guinea Pig, Daniorerio

产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 38kDa

细胞定位细胞核细胞浆

性状 Lyophilized or Liquid

浓度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human NIPP1:21-120/351

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed

产品介绍 Inhibitor subunit of the major nuclear protein phosphatase 1 (PP1). It has RNA binding activity but does not cleave RNA and may target PP1 to RNA associated substrates. May also be involved in pre mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.

NIPP1是一种普遍存在于细胞核中的蛋白，它在剪接体的装配中发挥着重要作用，主要体现在细胞的分化，增值及迁移中。经研究，目前NIPP1在乳腺肿瘤、前列腺癌,以及肺癌中有较高频率的表达,其中乳腺肿瘤中的表达频率高,达到70%,远高于其他肿瘤组织。表明ARD1蛋白的高表达可能是乳腺肿瘤组织的一个标志。