S100B蛋白

报价:¥1580
供货周期: 现货
品牌: LMAI Bio
型号: 50ul/100ul/200ul
货号: LM10832M
上海联迈生物工程有限公司
银牌会员7年生产商
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S100B蛋白

 

英文名称    S100B    

中文名称    S100B蛋白    

别    名    NEF; Protein S100 B; Protein S100-B; S 100 calcium binding protein beta chain; S 100 protein beta chain; S 100 protein beta subunit; S-100 protein beta chain; S-100 protein subunit beta; S100; S100 calcium binding protein B; S100 calcium binding protein beta (neural); S100 calcium binding protein beta chain; S100 calcium-binding protein B; S100 protein beta chain; S100B_HUMAN; S100beta; S100 β; S100-β; S100β.      

研究领域    肿瘤  细胞生物  神经生物学  细胞周期蛋白  细胞分化      

抗体来源    Mouse    

克隆类型    Monoclonal    

克 隆 号    1C6    

交叉反应    Human, Mouse, Rat,     

产品应用    ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    10kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/ml    

免 疫 原    KLH conjugated synthetic peptide derived from human S100B: 2-92/92aa (N-6x His-Tag)     

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

PubMed    PubMed    

产品介绍    S100 beta is a member of the S100 family of proteins containing 2 EF-hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.    

结构蛋白(Structural Proteins)
S100B是一组可溶性、相对低分子质量、高酸性蛋白,属神经胶质细胞特异性蛋白,亦可存在于神经纤维中。在研究肠神经系统的形态特征及结构特征中,S100B有良好的表达功能。 S100B蛋白其生理作用尚不清楚,可能与细胞内钙离子媒介的调节作用有关。S100B蛋白可存在于神经鞘瘤,成软骨细胞瘤、软骨肉瘤、骨肉瘤、神经胶质瘤、郎格罕斯细胞瘤、一些癌肿和黑素细胞肿瘤等。
在免疫组化中,除了恶性黑素瘤皮损,S100B蛋白还在良性黑素细胞痣中增加,如:蓝痣、普通后天痣、雀斑样痣、Spitz痣、气球状细胞痣、色素性梭形细胞痣和发育不良痣中表达。还有报道S100B蛋白的染色强度与肿瘤细胞的黑素含量呈负相关。结缔组织增生性的或亲神经的黑素瘤不易染色。

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S100B蛋白由上海联迈生物工程有限公司为您提供,货号LM10832M,规格:50ul/100ul/200ul,CAS号:,如您想了解更多关于S100B蛋白价格、S100B蛋白结构式、批发、用途等信息,欢迎咨询。除供应S100B蛋白外,还可为您提供Pescadillo抗体、磷酸化低密度脂蛋白受体相关蛋白6抗体等试剂,公司有专业的客户服务团队,是您值得信赖的合作伙伴,LMAI-BIO客户服务电话400-860-5168转4246,售前、售后均可联系。
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