供货周期: | 现货 |
品牌: | LMAI Bio |
规格: | 50ul/100ul/200ul |
货号: | LM33195M |
CAS号: |
细胞凋亡抑制因子单克隆抗体
英文名称 Survivin
中文名称 细胞凋亡抑制因子单克隆抗体
别 名 API4; API-4; API 4; Survivin variant 3 alpha; Apoptosis Inhibitor 4; Apoptosis inhibitor survivin; Apoptosis inhibitor4; Baculoviral IAP repeat containing 5; Baculoviral IAP repeat containing protein 5; Baculoviral IAP repeat-containing protein 5; BIRC 5; BIRC5; BIRC-5; EPR 1; EPR-1; IAP4; IAP-4; IAP 4; SVV; TIAP; BIRC5_HUMAN.
研究领域 肿瘤 细胞生物 免疫学 细胞凋亡
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 Mix-mA™
交叉反应 Human, Rat,
产品应用 WB=1:500-1000 ELISA=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 16kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Survivin:
亚 型 IgG
纯化方法 affinity purified by Protein G
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Interacts with tubulin. Inhibitor of caspase-3 and caspase-7. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Belongs to the IAP family.
Survivin是目前发现的最强的凋亡抑制因子,存活蛋白是细胞凋亡抑制基因家族中的一个新成员,主要表达于细胞周期中的G2/M期,在许多恶性肿瘤组织中均有表达,主要用于各种恶性肿瘤的研究。
是细胞凋亡的一种抑制因子、参与细胞凋亡调控,可以用于各种恶性肿瘤的细胞凋亡的研究。Survivin具有肿瘤特异性,只表达于肿瘤和胚胎组织,且与肿瘤细胞的分化增殖及浸润转移密切相关.
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