Carnosic acid

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抑制剂描述：

产品名称：Carnosic acid

产品别名：见爱必信官网

英文别名：Carnosic acid

靶点：Phenols

CAS：3650-09-7

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20° C

描述：

Carnosic acid is a phenolic diterpene, endowed with antioxidative and antimicrobial properties. It is increasingly used within food, nutritional health and cosmetics industries.

溶解性：DMSO ：66 mg/mL (198.54 mM)

体外研究：

Carnosic acid (CA) would inhibit the cell viability of three CRC cell lines: Caco-2, HT29 and LoVo in a dose-dependent manner, with IC50 values in the range of 24-96 μM. CA induces cell death by apoptosis in Caco-2 line after 24 h of treatment and inhibits cell adhesion and migration, possibly by reducing the activity of secreted proteases such as urokinase plasminogen activator (uPA) and metalloproteinases (MMPs). CA downregulates the expression of COX-2 in Caco-2 cells at both the mRNA and protein levels. CA induces antioxidant and anti-inflammatory effects in several cell types, as observed in both in vitro and in vivo experimental models. It exhibits the ability to promote mitochondrial protection in neural cells. In vitro, CA suppresses Receptor Activator for Nuclear Factor-κ B Ligand (RANKL)- and Macrophage colony-stimulating factor (M-CSF)-induced osteoclastogenesis. The osteoclastic specific markers are inhibited by CA. Signal transduction studies show that CA significantly decreases the expression of molecules contributing to ROS and increases anti-oxidants. Additionally, CA inactivates the RANKL- and M-CSF-induced p38 mitogen activated protein kinases (MAPK), inhibits NF-κB phosphorylation, causing pro-inflammatory cytokines down-regulation. CA ameliorates acute promyelocytic leukemia cells through activating nuclear transcription factor E2-related factor 2 (Nrf2), which plays an essential role in cytoprotective responses to oxidative stress.

体内研究：CA significantly down-regulates fasting blood glucose, glucose level in oral glucose tolerance test (OGTT) and insulin tolerance test (ITT), ameliorates CIA-induced bone loss, and reduces pro-inflammatory cytokines and reactive oxygen species (ROS) in db/db mice with arthritis induced by collagen-induced arthritis (CIA). CA could regulate ER stress to ameliorate disease progression. It can also cross the blood-brain barrier readily and exert its protective effects via its potent anti-oxidative role.

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