供货周期: | 一周 |
品牌: | 爱必信 |
规格: | ≥98% |
货号: | abs814804 |
CAS号: | 65914-17-2 |
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抑制剂描述: 产品名称:Polydatin 产品别名:见爱必信官网 英文别名:Polydatin 靶点:Phenols CAS:65914-17-2 纯度:≥98% 外观:见爱必信官网 保存方法:Store at -20° C 描述: Polydatin, or Piceid, is a natural precursor and glycoside form of resveratrol with a monocrystalline structure. While it is isolated from the bark of Picea sitchensis or Polygonum cuspidatum, Polydatin may be detected in grape, peanut, hop cones, red wines, hop pellets, cocoa-containing products, chocolate products and many daily diets. Polydatin possesses anti-inflammatory, immunoregulatory, anti-oxidative and anti-tumor activities. It is shown to mediate a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis. 溶解性:DMSO :78 mg/mL (199.81 mM) 体外研究: Polydatin, known as a PLA2 inhibitor, reduces Phospholipase A2 (PLA2) activity and sPLA2-IIA mRNA expression and mitigates LPS-induced lung injury by increasing increased Clara cell secretory protein (CCSP) expression. 体内研究:Pretreatment with Polydatin (15, 45, and 100 mg/kg) dose-dependently reduces sepsis-induced mortality and lung injury in cecal ligation and puncture (CLP-)induced sepsis mice through inhibiting CLP-induced serum tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production, lung cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase isoform (iNOS) protein expressions and NF-kappaB activation. LD50: Mice 1g/kg (i.p.)
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