供货周期: | 一周 |
品牌: | 爱必信 |
规格: | ≥97% |
货号: | abs42014845 |
CAS号: | 138977-28-3 |
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试剂描述: 产品名称:Capsazepine 产品别名:7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide CAS号:138977-28-3 英文别名:Capsazepine 分子量:376.90 分子式:C19H21ClN2O2S 纯度:≥97% 外观:见爱必信官网 保存方法:Store at -20° C 描述:Capsazepine is a competitive antagonist of the VR1 (TRPV1, also transient receptor potential vanilloid type 1), antagonizing the effects produced by Capsaicin at this receptor . The VR1 (TRPV1 receptor) is a non-selective ligand-gated cation channel that responds to noxious heat, protons, and Capsaicin, producing nociception signals. Capsazepine also activates ENaCδ (amiloride-sensitive epithelial Na+ channel). Capsazepine is shown to inhibit the development of mechanical hyperalgesia induced by intraplanar capsaicin injection. Capsazepine is described to block Resiniferatoxin - and Capsaicin-induced contractions of guinea pig treacheal smooth muscle. Studies investigating the function of the VR1 (TRPV1 receptor) have employed Capsazepine as a tool for perturbing systemic neuronal response to Capsaicin. 应用:An antagonist of TRPV1 and activator of ENaC
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