供货周期: | 一周 |
品牌: | 爱必信 |
规格: | ≥95% |
货号: | abs47045509 |
CAS号: | 192575-19-2 |
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试剂描述: 产品名称:PPADS (sodium salt) 产品别名:Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid; CAS号:192575-19-2 英文别名:PPADS (sodium salt) 分子量:599.3 分子式:C14H10N3O12PS2 ? 4Na 纯度:≥95% 外观:见爱必信官网 保存方法:Store at -20℃ 描述: P2X and P2Y purinergic receptors are ATP-sensitive receptors responsible for mediating a large variety of excitatory postsynaptic responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis. PPADS is a non-selective P2 purinergic antagonist that blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors.1 PPADS antagonism of ATP-sensitive P2 receptors produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats.2 应用:
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