供货周期: | 一周 |
品牌: | 爱必信 |
规格: | ≥95% |
货号: | abs47044767 |
CAS号: | 1161002-05-6 |
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试剂描述: 产品名称:G-15 产品别名: CAS号:1161002-05-6 英文别名:G-15 分子量:370.2 分子式:C19H16BrNO2 纯度:≥95% 外观:见爱必信官网 保存方法:Store at -20℃,3 years 描述: G protein-coupled estrogen receptor (GPER), or GPR30, specifically binds natural and man-made estrogens.1 It is thought to be involved in estrogen-sensitive cancers.1,2 GPER knockout mice are fertile, although they exhibit thymic atrophy, impaired glucose tolerance, and altered bone growth.1 G-15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM).3 It displays low affinity cross-reactivity with the classical estrogen receptor (ER), ERα, so that at doses greater than 1 μM it is capable of mediating limited ER-dependent transcriptional activity.4 G-15 antagonizes the anti-depressive effects of estrogen in vivo.3 应用:
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