供货周期: | 一周 |
品牌: | 爱必信 |
规格: | 10ug |
货号: | abs04185 |
CAS号: |
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产品描述: 产品名称:Recombinant Human Brain-Derived Neurotrophic Factor/BDNF 背景说明: Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease. 描述: Recombinant Human Brain-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding His129-Arg247 is expressed. 氨基酸序列: MHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYT KEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR 别名: Brain-Derived Neurotrophic Factor, BDNF, Abrineurin Accession: P23560 纯度: Greater than 95% as determined by reducing SDS-PAGE. 来源: Escherichia coli. 内毒素水平: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test. 活性: Measured by its ability to bind Human TrkB in functional ELISA. The ED50 for this effect is less than 5 ug/ml. 形态: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2. 溶解方法: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 储存/保存方法: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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