Recombinant Human Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His), 人蛋白Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His)|10ug|abs04340-爱必信(上海)生物科技有限公司

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产品描述：

产品名称：Recombinant Human Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His)

描述: Recombinant Human Nectin-1 is produced by our Mammalian expression system and the target gene encoding Gln31-Thr334 is expressed with a 6His tag at the C-terminus.

氨基酸序列: QVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRE RVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAK KGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLA CIVNYHMDRFKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLP KGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITVDHHHHHH

背景说明: Nectin-1 is a type I transmembrane glycoprotein belonging to the Ig superfamily. Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between Nectin-1 and Nectin-3 and between Nectin-1 and Nectin-4. Nectin ECDs contain three Ig like domains: an N terminal V type that mediates ligand binding, and two C2 type. Nectin-1 binds viral Glycoprotein D to mediate Herpesvirus (but not Poxvirus) entry into vaginal mucosa, sensory neurons and fibroblasts. In forming adherens junctions and synapses, Nectin-1 and Nectin-3 initiate cell-cell interactions, recruiting αvβ3 integrin extracellularly and cadherins intracellularly through afadin and other junctional proteins. These interactions organize the cytoskeleton, strengthen attachment to basement membrane and promote further cell-cell connections. Nectin-1 and Nectin-3 have been found to localize assymetrically along the chemical synapse, with Nectin-1 primarily on the axonal side and Nectin-3 on the dendritic side. Deficiency of Nectin-1 can result in cleft lip/palate ectodermal dysplasia. Nectin-1 downregulation in epithelial cancers is mediated in part by ectodomain shedding, but it may contribute to invasiveness.

别名: Poliovirus Receptor-Related Protein 1, Herpes Virus Entry Mediator C, Herpesvirus Entry Mediator C, HveC, Herpesvirus Ig-Like Receptor, HIgR, Nectin-1, CD111, PVRL1, HVEC, PRR1

Accession: Q15223

纯度: Greater than 95% as determined by reducing SDS-PAGE.

来源: Human Cells

内毒素水平: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.

溶解方法: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

形态: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs04340	Recombinant Human Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His)	10ug	672.00	立即咨询
abs04340	Recombinant Human Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His)	50ug	1848.00	立即咨询
abs04340	Recombinant Human Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His)	500ug	12936.00	立即咨询
abs04340	Recombinant Human Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His)	1mg	17600.00	立即咨询

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Recombinant Human Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His), 人蛋白Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His)由爱必信(上海)生物科技有限公司为您提供，货号abs04340，规格：10ug，CAS号：，如您想了解更多关于Recombinant Human Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His), 人蛋白Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His)价格、Recombinant Human Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His), 人蛋白Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His)结构式、批发、用途等信息，欢迎咨询。除供应Recombinant Human Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His), 人蛋白Poliovirus Receptor-Related Protein 1/PVRL1 (C-6His)外，还可为您提供其他等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，爱必信客户服务电话，售前、售后均可联系。

供货周期：	一周
品牌：	爱必信
规格：	10ug
货号：	abs04340
CAS号：