Recombinant Human PDCD1/PD-1/CD279 (C-mFc), 人蛋白PDCD1/PD-1/CD279 (C-mFc)|10ug|abs04359-爱必信(上海)生物科技有限公司

Recombinant Human PDCD1/PD-1/CD279 (C-mFc), 人蛋白PDCD1/PD-1/CD279 (C-mFc)

参考价：¥798

供货周期：

一周

品牌：

爱必信

规格：

10ug

货号：

abs04359

CAS号：

产品详情

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产品描述：

产品名称：Recombinant Human PDCD1/PD-1/CD279 (C-mFc)

描述: Recombinant Human Programmed Cell Death Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu25-Gln167 is expressed with a mFc tag at the C-terminus.

氨基酸序列: LDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQP GQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTA HPSPSPRPAGQFQPRDCGCKPCICTVPEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEV QFSWFVDDVEVHTAQTQPREEQFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISK TKGRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGS YFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK

背景说明: Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.

Accession: Q15116

别名: Programmed cell death protein 1,hPD-1,PDCD1,CD279

来源: Human Cells

纯度: Greater than 95% as determined by reducing SDS-PAGE.

内毒素水平: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.

形态: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

溶解方法: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs04359	Recombinant Human PDCD1/PD-1/CD279 (C-mFc)	10ug	798.00	立即咨询
abs04359	Recombinant Human PDCD1/PD-1/CD279 (C-mFc)	50ug	2100.00	立即咨询
abs04359	Recombinant Human PDCD1/PD-1/CD279 (C-mFc)	500ug	12936.00	立即咨询
abs04359	Recombinant Human PDCD1/PD-1/CD279 (C-mFc)	1mg	17600.00	立即咨询

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