供货周期: | 一周 |
品牌: | 爱必信 |
规格: | 10ug |
货号: | abs04535 |
CAS号: |
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产品描述: 产品名称:Recombinant Human KIR2DL3/NKAT2/CD158b2 (C-6His) 描述: Recombinant Human KIR2DL3 is produced by our Mammalian expression system and the target gene encoding His22-His245 is expressed with a 6His tag at the C-terminus. 氨基酸序列: HEGVHRKPSLLAHPGPLVKSEETVILQCWSDVRFQHFLLHREGKFKDTLHLIGEHHDGVSKANFS IGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSS RSSYDMYHLSREGEAHERRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPL LVSVTGNPSNSWLSPTEPSSETGNPRHLHHHHHHH 背景说明: Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis. 别名: Killer Cell Immunoglobulin-Like Receptor 2DL3, CD158 Antigen-Like Family Member B2, KIR-023GB, Killer Inhibitory Receptor cl 2-3, MHC Class I NK Cell Receptor, NKAT2a, NKAT2b, Natural Killer-Associated Transcript 2, NKAT-2, p58 Natural Killer Cell Receptor Clone CL-6, p58 NK Receptor CL-6, p58.2 MHC Class-I-Specific NK Receptor, CD158b2, KIR2DL3, CD158B2, KIRCL23, NKAT2 Accession: P43628 纯度: Greater than 95% as determined by reducing SDS-PAGE. 来源: Human Cells 内毒素水平: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test. 溶解方法: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 形态: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
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