供货周期: | 一周 |
品牌: | 爱必信 |
规格: | 10ug |
货号: | abs04569 |
CAS号: |
公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
产品描述: 产品名称:Recombinant Mouse Platelet Receptor Gi24/VISTA/B7-H5 (C-6His) 背景说明: Mouse Platelet receptor Gi24(VISTA) is a transmembrane glycoprotein with homology to B7like immune costimulatory molecules. Mature mouse Gi24 contains a 159 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane segment, and a 97 aa cytoplasmic domain. VISTA promotes both MT1-MMP expression and the MT1-MMP mediated activation of MMP-2. It supports the differentiation of embryonic stem cells (ESC) and enhances BMP-4 induced signaling in ESC, but it is also down-regulated following BMP-4 exposure. It binds to BMP-4 directly and also associates with the type I BMP receptor Activin RIB/ALK-4. It is expressed on the surface of na?ve CD4+ T cells and regulatory T cells. It is up-regulated in vivo on activated monocytes and dendritic cells. VISTA inhibits CD4+ and CD8+ T cell proliferation and their production of IL-2 and IFN-γ. Its expression on tumor cells attenuates the antitumor immune response and enables more rapid tumor progression. 描述: Recombinant Mouse Platelet receptor Gi24 is produced by our Mammalian expression system and the target gene encoding Phe33-Ala191 is expressed fused with a 6His tag at the C-terminus. 氨基酸序列: FKVTTPYSLYVCPEGQNATLTCRILGPVSKGHDVTIYKTWYLSSRGEVQMCKEHRPIRNFTLQHL QHHGSHLKANASHDQPQKHGLELASDHHGNFSITLRNVTPRDSGLYCCLVIELKNHHPEQRFYGS MELQVQAGKGSGSTCMASNEQDSDSITAAHHHHHH 别名: Platelet receptor Gi24; stress induced secreted protein 1; Dies1; VISTA; SISP1; B7-H5; PD-1H;GI24 Accession: Q9D659 纯度: Greater than 95% as determined by reducing SDS-PAGE. 来源: Human Cells 内毒素水平: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test. 形态: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. 溶解方法: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
产品信息订购:
|
相关产品
Recombinant 2019-nCoV S-trimer Protein (C-6His)
2500
Recombinant 2019-nCoV S protein RBD Protein (C-mFc)
1700
Recombinant 2019-nCoV S Protein RBD-SD1 (C-6His)
1700
Recombinant 2019-nCoV S Protein RBD-SD1 (C-mFC)
1700
Recombinant 2019-nCoV S1 Protein (C-Fc)
1700
Recombinant 2019-nCoV S Protein RBD (C-6His)
1700
Recombinant 2019-nCoV S2 Protein (C-Fc)
1700
Recombinant Human PD-1/PDCD1/CD279, 人蛋白PD-1/PDCD1/CD279
798
详细地址
关注
拨打电话
留言咨询