Recombinant Mouse SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His), 小鼠蛋白SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His)|10ug|abs04580-爱必信(上海)生物科技有限公司

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产品名称：Recombinant Mouse SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His)

描述: Recombinant Mouse Natural killer cell receptor 2B4 is produced by our Mammalian expression system and the target gene encoding Gln20-Asn221 is expressed with a 6His tag at the C-terminus.

氨基酸序列: QDCPDSSEEVVGVSGKPVQLRPSNIQTKDVSVQWKKTEQGSHRKIEILNWYNDGPSWSNVSFSDI YGFDYGDFALSIKSAKLQDSGHYLLEITNTGGKVCNKNFQLLILDHVETPNLKAQWKPWTNGTCQ LFLSCLVTKDDNVSYALYRGSTLISNQRNSTHWENQIDASSLHTYTCNVSNRASWANHTLNFTHG CQSVPSNHHHHHH

背景说明: Natural killer cell receptor 2B4 (2B4/CD244) is is a 66 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family. SLAM family proteins have an extracellular domain (ECD) with two or four Ig-like domains and at least two cytoplasmic immunoreceptor tyrosine-based switch motifs (ITSMs). 2B4 interacts with CD48, while other SLAM family proteins interact in a homophilic manner. The mouse 2B4 cDNA encodes a 397 amino acid (aa) precursor that includes a 19 aa signal sequence, a 207 aa ECD with one Ig-like V-type and one C2-type Ig-like domain, a 21 aa transmembrane segment, and a 150 aa cytoplasmic domain with four ITSMs. Within the ECD, mouse 2B4 shares 46% and 68% aa sequence identity with human and rat 2B4, respectively. 2B4/CD48 signaling cooperates with other receptor systems to either promote or inhibit NK and CD8+ T cell activation. The inhibitory activities are distinct from those of MHC I restricted inhibitory NK cell receptors. Ligation of 2B4 with antibodies or CD48 constructs can directly trigger inhibitory signaling or disrupt an inhibitory interaction, leading to cellular activation. 2B4 can also induce signaling through CD48.

别名: Natural killer cell receptor 2B4; NK cell type I receptor protein 2B4; NKR2B4; SLAM family member 4; SLAMF4; Signaling lymphocytic activation molecule 4; CD244

Accession: Q07763

纯度: Greater than 95% as determined by reducing SDS-PAGE.

来源: Human Cells

内毒素水平: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.

溶解方法: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

形态: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs04580	Recombinant Mouse SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His)	10ug	798.00	立即咨询
abs04580	Recombinant Mouse SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His)	50ug	2100.00	立即咨询
abs04580	Recombinant Mouse SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His)	500ug	12936.00	立即咨询
abs04580	Recombinant Mouse SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His)	1mg	17600.00	立即咨询

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Recombinant Mouse SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His), 小鼠蛋白SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His)由爱必信(上海)生物科技有限公司为您提供，货号abs04580，规格：10ug，CAS号：，如您想了解更多关于Recombinant Mouse SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His), 小鼠蛋白SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His)价格、Recombinant Mouse SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His), 小鼠蛋白SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His)结构式、批发、用途等信息，欢迎咨询。除供应Recombinant Mouse SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His), 小鼠蛋白SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His)外，还可为您提供其他等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，爱必信客户服务电话，售前、售后均可联系。

供货周期：	一周
品牌：	爱必信
规格：	10ug
货号：	abs04580
CAS号：