供货周期: | 一周 |
品牌: | 爱必信 |
规格: | 10ug |
货号: | abs04580 |
CAS号: |
公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
产品描述: 产品名称:Recombinant Mouse SLAMF4/Natural killer cell receptor 2B4/CD244 (C-6His) 描述: Recombinant Mouse Natural killer cell receptor 2B4 is produced by our Mammalian expression system and the target gene encoding Gln20-Asn221 is expressed with a 6His tag at the C-terminus. 氨基酸序列: QDCPDSSEEVVGVSGKPVQLRPSNIQTKDVSVQWKKTEQGSHRKIEILNWYNDGPSWSNVSFSDI YGFDYGDFALSIKSAKLQDSGHYLLEITNTGGKVCNKNFQLLILDHVETPNLKAQWKPWTNGTCQ LFLSCLVTKDDNVSYALYRGSTLISNQRNSTHWENQIDASSLHTYTCNVSNRASWANHTLNFTHG CQSVPSNHHHHHH 背景说明: Natural killer cell receptor 2B4 (2B4/CD244) is is a 66 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family. SLAM family proteins have an extracellular domain (ECD) with two or four Ig-like domains and at least two cytoplasmic immunoreceptor tyrosine-based switch motifs (ITSMs). 2B4 interacts with CD48, while other SLAM family proteins interact in a homophilic manner. The mouse 2B4 cDNA encodes a 397 amino acid (aa) precursor that includes a 19 aa signal sequence, a 207 aa ECD with one Ig-like V-type and one C2-type Ig-like domain, a 21 aa transmembrane segment, and a 150 aa cytoplasmic domain with four ITSMs. Within the ECD, mouse 2B4 shares 46% and 68% aa sequence identity with human and rat 2B4, respectively. 2B4/CD48 signaling cooperates with other receptor systems to either promote or inhibit NK and CD8+ T cell activation. The inhibitory activities are distinct from those of MHC I restricted inhibitory NK cell receptors. Ligation of 2B4 with antibodies or CD48 constructs can directly trigger inhibitory signaling or disrupt an inhibitory interaction, leading to cellular activation. 2B4 can also induce signaling through CD48. 别名: Natural killer cell receptor 2B4; NK cell type I receptor protein 2B4; NKR2B4; SLAM family member 4; SLAMF4; Signaling lymphocytic activation molecule 4; CD244 Accession: Q07763 纯度: Greater than 95% as determined by reducing SDS-PAGE. 来源: Human Cells 内毒素水平: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test. 溶解方法: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 形态: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
产品信息订购:
|
相关产品
Recombinant 2019-nCoV S-trimer Protein (C-6His)
2500
Recombinant 2019-nCoV S protein RBD Protein (C-mFc)
1700
Recombinant 2019-nCoV S Protein RBD-SD1 (C-6His)
1700
Recombinant 2019-nCoV S Protein RBD-SD1 (C-mFC)
1700
Recombinant 2019-nCoV S2 Protein (C-Fc)
1700
Recombinant 2019-nCoV S1 Protein (C-Fc)
1700
Recombinant 2019-nCoV S Protein RBD (C-6His)
1700
Recombinant Human PD-1/PDCD1/CD279, 人蛋白PD-1/PDCD1/CD279
798
详细地址
关注
拨打电话
留言咨询