Recombinant Human HVEM/TNFRSF14/CD270 (C-6His), 人蛋白HVEM/TNFRSF14/CD270 (C-6His)|10ug|abs04595-爱必信(上海)生物科技有限公司

Recombinant Human HVEM/TNFRSF14/CD270 (C-6His), 人蛋白HVEM/TNFRSF14/CD270 (C-6His)

参考价：¥420

供货周期：

一周

品牌：

爱必信

规格：

10ug

货号：

abs04595

CAS号：

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产品描述：

产品名称：Recombinant Human HVEM/TNFRSF14/CD270 (C-6His)

描述: Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 14/TNFRSF14 is produced by our Mammalian expression system and the target gene encoding Leu39-Val202 is expressed with a 6His tag at the C-terminus.

氨基酸序列: LPSCKEDEYPVGSECCPKCSPGYRVKEACGELTGTVCEPCPPGTYIAHLNGLSKCLQCQMCDPAM GLRASRNCSRTENAVCGCSPGHFCIVQDGDHCAACRAYATSSPGQRVQKGGTESQDTLCQNCPPG TFSPNGTLEECQHQTKCSWLVTKAGAGTSSSHWVVDHHHHHH

背景说明: Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on na?ve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding.

别名: Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM

Accession: Q92956

纯度: Greater than 90% as determined by reducing SDS-PAGE.

来源: Human Cells

内毒素水平: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.

形态: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

溶解方法: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs04595	Recombinant Human HVEM/TNFRSF14/CD270 (C-6His)	10ug	420.00	立即咨询
abs04595	Recombinant Human HVEM/TNFRSF14/CD270 (C-6His)	50ug	1008.00	立即咨询
abs04595	Recombinant Human HVEM/TNFRSF14/CD270 (C-6His)	500ug	5040.00	立即咨询
abs04595	Recombinant Human HVEM/TNFRSF14/CD270 (C-6His)	1mg	7200.00	立即咨询

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