供货周期: | 一周 |
品牌: | 爱必信 |
规格: | 1mg |
货号: | abs813891 |
CAS号: | 210344-98-2 |
公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
产品描述: 产品名称:Z-IETD-FMK 描述: Z-IETD-FMK is a specific Caspase-8 inhibitor. 别名: Caspase-8 Inhibitor;Z-IE(OMe)TD(OMe)-FMK CAS号: 210344-98-2 靶点: Caspase-8 In vitro(体外研究): Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures. 分子式: C30H43FN4O11 In vivo(体内研究): In vivo, inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells, and increases susceptibility to T. cruzi infection. Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries. 分子量: 654.68 纯度: 98% 储存/保存方法: store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 可溶性/溶解性: DMSO :84 mg/mL (128.3 mM)
产品信息订购:
|
相关产品
详细地址
关注
拨打电话
留言咨询