供货周期: | 一周 |
品牌: | 爱必信 |
规格: | 100mg |
货号: | abs814785 |
CAS号: | 99-32-1 |
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产品描述: 产品名称:Chelidonic acid 描述: Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM. 别名: 白屈菜酸;Jerva acid;Jervaic acid; γ-Pyrone-2;6-dicarboxylic acid CAS号: 99-32-1 靶点: NF-κB,Caspase-1,Glutamate decarboxylase In vitro(体外研究): Chelidonic acid dose-dependently decreases IL-6 production at 0.1-10 μM, inhibits expression of IL-6 mRNA at 1-10 μM. Chelidonic acid (0.1-10 μM) decreases caspase-1 activation, nuclear NF-κB activation, and increases cytosol NF-κB activation. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM. Chelidonic acid does not promote formation of apoenzyme or react with free pyridoxal-P. 分子式: C7H4O6 外观: Beige to brown powder In vivo(体内研究): Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice. 分子量: 184.10 纯度: >98% 储存/保存方法: Store at -20°C 产品用途: 科研试剂,用于有机合成。 可溶性/溶解性: DMSO :4 mg/mL (21.72 mM)
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