Emricasan|5mg|abs816139-爱必信(上海)生物科技有限公司

Emricasan

参考价：¥1035

供货周期：

一周

品牌：

爱必信

规格：

5mg

货号：

abs816139

CAS号：

254750-02-2

产品详情

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

产品描述：

产品名称：Emricasan

描述:

Emricasan is a potent irreversible <b>pan-caspase</b> inhibitor.

参考文献:

[1] Barreyro FJ, et al. Liver Int. 2015, 35(3):953-66.

[2] Xu M, et al. Nat Med. 2016, [Epub ahead of print].

CAS号: 254750-02-2

靶点: caspase

In vitro(体外研究): Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan shows neuroprotective activity for hNPCs but does not suppress ZIKV replication.

分子式: C₂₆H₂₇F₄N₃O₇

In vivo(体内研究): Emricasan decreases liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of the pan-caspase inhibitor Emricasan. Emricasan is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection.

分子量: 569.50

纯度: 99.00 %

储存/保存方法: store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

可溶性/溶解性: 体外:
DMSO 100mg/mL(175.59mM)
Ethanol 100mg/mL(175.59mM)
Water <1mg/mL

产品信息订购：

产品货号	产品名称	规格	价格	大包装及货期
abs816139	Emricasan	5mg	1035.00	立即咨询
abs816139	Emricasan	25mg	3768.00	立即咨询

产品更多信息请进入爱必信网站咨询